1-Bromo-2-[(cyclopent-3-en-1-yl)methyl]-3,4-difluorobenzene

Base Information

Chemical Name:1-Bromo-2-[(cyclopent-3-en-1-yl)methyl]-3,4-difluorobenzene
CAS No.:922166-21-0
Molecular Formula:C12H11BrF2
Molecular Weight:273.12
Hs Code.:
DSSTox Substance ID:DTXSID30580421

Synonyms:922166-21-0;DTXSID30580421;1-Bromo-2-[(cyclopent-3-en-1-yl)methyl]-3,4-difluorobenzene

Suppliers and Price of 1-Bromo-2-[(cyclopent-3-en-1-yl)methyl]-3,4-difluorobenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-Bromo-2-[(cyclopent-3-en-1-yl)methyl]-3,4-difluorobenzene

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:272.00122
Heavy Atom Count:15
Complexity:234

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C=CCC1CC2=C(C=CC(=C2F)F)Br

Technology Process of 1-Bromo-2-[(cyclopent-3-en-1-yl)methyl]-3,4-difluorobenzene

There total 4 articles about 1-Bromo-2-[(cyclopent-3-en-1-yl)methyl]-3,4-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 348-61-8
1-bromo-3,4-difluorobenzene

: 140380-11-6
trifluoromethanesulfonic acid cyclopent-3-enylmethyl ester

: 922166-21-0
1-bromo-2-(cyclopent-3-enylmethyl)-3,4-difluorobenzene

Guidance literature:: 1-bromo-3,4-difluorobenzene; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -70 ℃; for 1.5h;

trifluoromethanesulfonic acid cyclopent-3-enylmethyl ester; In tetrahydrofuran; hexane; at -70 ℃;
DOI:10.1021/ol0623062

Reference yield:

: 25125-21-7
4-(hydroxymethyl)cyclopentene

: 922166-21-0
1-bromo-2-(cyclopent-3-enylmethyl)-3,4-difluorobenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / hexane / 1 h / 0 - 5 °C

1.2: 75 percent / hexane / 1 h / 10 - 15 °C

2.1: LDA / tetrahydrofuran; hexane / 1.5 h / -70 °C

2.2: 92 percent / tetrahydrofuran; hexane / -70 °C

With pyridine; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/ol0623062

Reference yield:

: 7686-77-3
3-cyclopentene-1-carboxylic acid

: 922166-21-0
1-bromo-2-(cyclopent-3-enylmethyl)-3,4-difluorobenzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiAlH₄ / tetrahydrofuran; toluene / 20 - 25 °C

2.1: pyridine / hexane / 1 h / 0 - 5 °C

2.2: 75 percent / hexane / 1 h / 10 - 15 °C

3.1: LDA / tetrahydrofuran; hexane / 1.5 h / -70 °C

3.2: 92 percent / tetrahydrofuran; hexane / -70 °C

With pyridine; lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; hexane; toluene;
DOI:10.1021/ol0623062