25125-21-7Relevant articles and documents
Rapid synthesis of (±)-r-7-benzyloxymethyl-cyclopenta-cis-[4,5][1,3]-oxazolo[3,2-a] pyrimidinones versatile carbocyclic nucleoside precursors
Pérez, Nury,Gordillo, Barbara
, p. 671 - 676 (2003)
(±)-r-7-Benzyloxymethyl-cyclopenta-cis-[4,5][1,3]-oxazolo[3,2-a] pyrimidinones were synthesized in two steps from 1-hydroxymethyl-3-cyclopentene. These compounds are versatile intermediates for the synthesis of carbocyclic nucleosides. The synthesis has been accomplished by the iodofunctionalization of olefins as a method of coupling the pyrimidine bases and the carbocycle.
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Olah,G.A.,Prakash,G.K.,Arvanaghi,M.
, p. 7105 (1982)
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Ruthenabenzene: A Robust Precatalyst
Gupta, Saswata,Su, Siyuan,Zhang, Yu,Liu, Peng,Wink, Donald J.,Lee, Daesung
supporting information, p. 7490 - 7500 (2021/05/26)
Metallaaromatics constitute a unique class of aromatic compounds where one or more transition metal elements are incorporated into the aromatic system, the parent of which is metallabenzene. One of the main concerns about metallabenzenes generally deals with the structural characterization related to their relative aromaticity compared to the carbon archetype. Transition metal-containing metallabenzenes are also implicated in certain catalytic processes such as alkyne metathesis polymerization; however, these transition metal-based metallaaromatic compounds have not been developed as a catalyst. Herein, we describe an effective strategy to generate diverse arrays of ruthenabenzenes and demonstrated them as an aromatic equivalent of the Grubbs-type ruthenium alkylidene catalysts. These ruthenabenzenes can be prepared via an enyne metathesis and metallotropic [1,3]-shift cascade process to form alkyne-chelated ruthenium alkylidene intermediates followed by spontaneous cycloaromatization. The aromatic nature of these complexes was confirmed by spectroscopic and X-ray crystallographic data, and the mechanistic pathways for the cycloaromatization process were studied by DFT calculations. These ruthenabenzenes display robust catalytic activity for metathesis and other transformations, which illustrates that metallabenzenes are not only compounds of structural and theoretical interests but also are a novel platform for new catalyst development.
Preparation method and intermediate of fused tricyclic derivative
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Paragraph 0098-0104, (2020/08/27)
The invention provides a preparation method of a fused tricyclic derivative intermediate. The intermediate has a structure shown as a formula (4-7). The preparation method has the advantages of accessible raw materials and simple steps and is suitable for large-scale industrial production.
TARGETED COMPOSITIONS
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Page/Page column 120; 121, (2018/11/10)
The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
