Ethyl 2-(4-methoxyphenyl)propanoate

Base Information

• Chemical Name: Ethyl 2-(4-methoxyphenyl)propanoate
• CAS No.: 2901-41-9
• Molecular Formula: C12H16 O3
• Molecular Weight: 208.257
• NSC Number: 85711
• DSSTox Substance ID: DTXSID80964676
• Nikkaji Number: J942.740F
• Mol file: 2901-41-9.mol

Synonyms:ethyl 2-(4-methoxyphenyl)propanoate;2901-41-9;NSC85711;SCHEMBL490908;DTXSID80964676;GGWHMTMLIFDQOU-UHFFFAOYSA-N;NSC-85711;ethyl 2-(4-methoxy-phenyl)propionate

Chemical Property of Ethyl 2-(4-methoxyphenyl)propanoate

Chemical Property:

• Vapor Pressure: 0.0034mmHg at 25°C
• Boiling Point: 282.2°Cat760mmHg
• Flash Point: 113.5°C
• Density: 1.041g/cm³
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 208.109944368
• Heavy Atom Count: 15
• Complexity: 195

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C)C1=CC=C(C=C1)OC

Technology Process of Ethyl 2-(4-methoxyphenyl)propanoate

There total 20 articles about Ethyl 2-(4-methoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethanol (64-17-5) + 4-Methoxypropiophenone (121-97-1) → 2-(4-methoxyphenyl)ethyl propionate (2901-41-9)

Guidance literature:

With perchloric acid; orthoformic acid triethyl ester; thallium(III) toluene-p-sulfonate; at 0 - 20 ℃; for 1.5h; Reagent/catalyst; Temperature;

DOI:10.5012/jkcs.2017.61.3.125

Reference yield: 84.0%

trifluoro-(4-methoxyphenyl)silane (50625-30-4) + 2-chloro-propanoic acid, ethyl ester (535-13-7) → 2-(4-methoxyphenyl)ethyl propionate (2901-41-9)

Guidance literature:

With (1,2-dimethoxyethane)dichloronickel(II); (1S,2R)-(+)-norphedrine; lithium hexamethyldisilazane; water; cesium fluoride; In N,N-dimethyl acetamide; at 60 ℃; for 16h;

DOI:10.1002/anie.200700440

Reference yield: 83.0%

orthoformic acid triethyl ester (122-51-0) + 4-Methoxypropiophenone (121-97-1) → 2-(4-methoxyphenyl)ethyl propionate (2901-41-9)

Guidance literature:

With perchloric acid; lead(IV) tetraacetate; at 20 ℃; for 2h;

DOI:10.5012/jkcs.2014.58.6.569

upstream raw materials:

2-Bromo-1,1-diethoxy-1-(4-methoxyphenyl)propane

2-chloro-1-(4'-methoxyphenyl)-propan-1-one

orthoformic acid triethyl ester

ethyl p-methoxyphenylacetate

Downstream raw materials:

1-(2-Hydroxy-4-methoxyphenyl)-2-(4-methoxyphenyl)propan-1-one

1-(2,4-dimethoxyphenyl)-2-(4-methoxyphenyl)propan-1-one

O-desmethylangolensin

(+/-)-2,3-Bis-(4-methoxy-phenyl)-but-1-en