4-(4-Chlorophenyl)-3-(2-fluorophenyl)butan-2-one

Base Information

Chemical Name:4-(4-Chlorophenyl)-3-(2-fluorophenyl)butan-2-one
CAS No.:922501-78-8
Molecular Formula:C16H14ClFO
Molecular Weight:276.73300
Hs Code.:
DSSTox Substance ID:DTXSID30582647

Synonyms:4-(4-Chlorophenyl)-3-(2-fluorophenyl)butan-2-one;922501-78-8;DTXSID30582647

Suppliers and Price of 4-(4-Chlorophenyl)-3-(2-fluorophenyl)butan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-(4-Chlorophenyl)-3-(2-fluorophenyl)butan-2-one

Chemical Property:

PSA：17.07000
LogP:4.39440
XLogP3:4.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:276.0717209
Heavy Atom Count:19
Complexity:299

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C(CC1=CC=C(C=C1)Cl)C2=CC=CC=C2F

Technology Process of 4-(4-Chlorophenyl)-3-(2-fluorophenyl)butan-2-one

There total 4 articles about 4-(4-Chlorophenyl)-3-(2-fluorophenyl)butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 922501-66-4
3-(4-chloro-phenyl)-2-(2-fluoro-phenyl)-propionic acid methyl ester

: 922501-78-8
4-(4-chloro-phenyl)-3-(2-fluoro-phenyl)-butan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: Me₂AlCl / 20 °C

2: 0 °C

With dimethylaluminum chloride;
DOI:10.1021/jm060996+

Reference yield:

: 57486-67-6
methyl o-fluorophenylacetate

: 922501-78-8
4-(4-chloro-phenyl)-3-(2-fluoro-phenyl)-butan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hexamethyldisilazide / -78 - 20 °C

2: Me₂AlCl / 20 °C

3: 0 °C

With sodium hexamethyldisilazane; dimethylaluminum chloride;
DOI:10.1021/jm060996+

Reference yield:

: 622-95-7
4-chlorobenzyl bromide

: 922501-78-8
4-(4-chloro-phenyl)-3-(2-fluoro-phenyl)-butan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hexamethyldisilazide / -78 - 20 °C

2: Me₂AlCl / 20 °C

3: 0 °C

With sodium hexamethyldisilazane; dimethylaluminum chloride;
DOI:10.1021/jm060996+