2,6-Bis(p-tolyl)pyridine

Base Information

• Chemical Name: 2,6-Bis(p-tolyl)pyridine
• CAS No.: 14435-88-2
• Molecular Formula: C19H17N
• Molecular Weight: 259.351
• Hs Code.: 2933399090
• European Community (EC) Number: 238-409-3
• UNII: TL77X5FD9V
• DSSTox Substance ID: DTXSID70162684
• Nikkaji Number: J151.255B
• Wikidata: Q83031421
• Mol file: 14435-88-2.mol

Synonyms:2,6-Bis(p-tolyl)pyridine;14435-88-2;2,6-Bis(4-methylphenyl)pyridine;2,6-DI-P-TOLYLPYRIDINE;Pyridine, 2,6-bis(4-methylphenyl)-;Pyridine, 2,6-di-p-tolyl-;EINECS 238-409-3;2,6-di(4-methylphenyl)pyridine;2,6-di-(4-Methylphenyl)pyridine;2,6-dip-tolylpyridine;2,6 Di-p-tolylpyridine;2,6-Di-p-tolyl-pyridine;Pyridine,2,6-di-p-tolyl-;TL77X5FD9V;SCHEMBL3421833;METHYL4-ISOPROPYLBENZOATE;DTXSID70162684;MFCD00006282;AKOS015842523;AS-40674;CS-0328715;FT-0637080

Chemical Property of 2,6-Bis(p-tolyl)pyridine

Chemical Property:

• Appearance/Colour: crystalline colorless to light yellow solid
• Vapor Pressure: 2.54E-06mmHg at 25°C
• Melting Point: 163-165 °C
• Refractive Index: 1.592
• Boiling Point: 402.5 °C at 760 mmHg
• Flash Point: 175.2 °C
• PSA: 12.89000
• Density: 1.055 g/cm³
• LogP: 5.03240
• XLogP3: 5.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 259.136099547
• Heavy Atom Count: 20
• Complexity: 256

Purity/Quality:

98%Min ^*data from raw suppliers

2,6-Di-p-tolylpyridine 97% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 22-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=NC(=CC=C2)C3=CC=C(C=C3)C

Technology Process of 2,6-Bis(p-tolyl)pyridine

There total 38 articles about 2,6-Bis(p-tolyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-dichloropyridine (2402-78-0) + potassium (4-methylphenyl)trifluoroborate → 2,6-di-p-tolylpyridine (14435-88-2)

Guidance literature:

With N-methyl-2-phenyl-3-(dicyclohexylphosphino)-1H-indole; palladium diacetate; triethylamine; sodium t-butanolate; In water; at 100 ℃; for 18h; Inert atmosphere; Schlenk technique;

DOI:10.1055/s-0033-1338660

Reference yield: 99.0%

2,6-dichloropyridine (2402-78-0) + para-methylphenylmagnesium bromide (4294-57-9) → 2,6-di-p-tolylpyridine (14435-88-2)

Guidance literature:

With chloro(1,3-bis(pyridin-2-ylmethyl)imidazolylidene)nickel(II) hexafluorophosphate; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.jorganchem.2011.09.008

Reference yield: 99.0%

2,6-Dibromopyridine (626-05-1) + 4-methylphenylboronic acid (5720-05-8) → 2,6-di-p-tolylpyridine (14435-88-2)

Guidance literature:

With potassium phosphate tribasic trihydrate; trans-[(2-mesitylpy)₂PdCl₂]; In methanol; water; at 80 ℃; for 1h;

DOI:10.1134/S0022476620030130

upstream raw materials:

rel-(2S,4R,6R,8S)-3,7-Dichlor-2,4,6,8-tetrakis(4-methylphenyl)-3,7-diazabicyclo<3.3.1>nonan

hex-3-yne

para-methylbenzonitrile

rel-(2S,4R,6R,8S)-2,4,6,8-Tetrakis(4-methylphenyl)-3,7-diazabicyclo<3.3.1>nonan

Downstream raw materials:

2-(4-Bromomethyl-phenyl)-6-p-tolyl-pyridine

2,6-bis<4'-(bromomethyl)phenyl>pyridine

cis-2,6-di(p-tolyl)piperidine

{Ir(ditolpyH)H(PPh₃)2}SbF₆