Cilomilast

Base Information

Chemical Name:Cilomilast
CAS No.:153259-65-5
Molecular Formula:C20H25NO4
Molecular Weight:343.423
Hs Code.:
UNII:8ATB1C1R6X
DSSTox Substance ID:DTXSID6046686,DTXSID40861410
Nikkaji Number:J1.788.364J,J949.726I,J949.729C
Wikipedia:Cilomilast
Wikidata:Q5120034
NCI Thesaurus Code:C95232
Pharos Ligand ID:TLMDQHHGLJS1
ChEMBL ID:CHEMBL511115,CHEMBL32854,CHEMBL27220
Mol file:153259-65-5.mol

Synonyms:Ariflo;Cilomilast;SB 207499

Suppliers and Price of Cilomilast

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Cilomilast
50mg
$ 2365.00

Sigma-Aldrich
Cilomilast ≥95% (HPLC)
25mg
$ 608.00

Sigma-Aldrich
Cilomilast ≥95% (HPLC)
5mg
$ 151.00

Medical Isotopes, Inc.
Cilomilast
50 mg
$ 3000.00

DC Chemicals
Cilomilast >98%
1 g
$ 2600.00

CSNpharm
Cilomilast
50mg
$ 464.00

CSNpharm
Cilomilast
5mg
$ 83.00

Crysdot
Cilomilast 98+%
10mg
$ 109.00

Crysdot
Cilomilast 98+%
5mg
$ 63.00

Crysdot
Cilomilast 98+%
100mg
$ 586.00

Total 38 raw suppliers

Chemical Property of Cilomilast

Chemical Property:

Appearance/Colour:White solid
Vapor Pressure:6.87E-13mmHg at 25°C
Melting Point:157 °C
Refractive Index:1.568
Boiling Point:549.06 °C at 760 mmHg
PKA:4.45±0.25(Predicted)
Flash Point:285.862 °C
PSA：79.55000
Density:1.215 g/cm³
LogP:4.05278
Storage Temp.:?20°C
Solubility.:DMSO: soluble15mg/mL, clear
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:343.17835828
Heavy Atom Count:25
Complexity:511

Purity/Quality:

97% ^*data from raw suppliers

Cilomilast ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)C2(CCC(CC2)C(=O)O)C#N)OC3CCCC3
Uses Cilomilast is a selective phosphodiesterase 4 (PDE4) inhibitor and can be used in treatment of chronic obstructive pulmonary disease. Selective phosphodiesterase 4 (PDE4) inhibitor. Antiasthmatic; used in treatment of chronic obstructive pulmonary disease.

Technology Process of Cilomilast

There total 25 articles about Cilomilast which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%