methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]

Base Information

Chemical Name:methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]
CAS No.:153259-61-1
Molecular Formula:C₂₁H₂₇NO₄
Molecular Weight:357.45
Hs Code.:

Synonyms:methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]

Suppliers and Price of methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]

There total 4 articles about methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

: 67-56-1
methanol

: 153260-05-0
2-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexylidene]-1,3-dithiane

: 153259-61-1
methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]

: 153259-62-2
methyl cis-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]

Guidance literature:: With perchloric acid; mercury dichloride; a) reflux, 2 h, b) RT, 42 h;
DOI:10.1021/jm970090r

Reference yield:

: (1R,5S)-5-Cyano-5-(3-cyclopentyloxy-4-methoxy-phenyl)-2-oxo-cyclohexanecarboxylic acid methyl ester

: 153259-61-1
methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / aq. NaCl / dimethylsulfoxide / 5 h / 140 - 145 °C

2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, -78 deg C, 10 min

3: 56 percent / HgCl₂, HClO₄ / a) reflux, 2 h, b) RT, 42 h

With n-butyllithium; perchloric acid; sodium chloride; mercury dichloride; In dimethyl sulfoxide;
DOI:10.1021/jm970090r

Reference yield:

: 152630-47-2
4-cyano-4-[3-(cyclopentyloxy)-4-methoxyphenyl]cyclohexan-1-one

: 153259-61-1
methyl trans-[4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)cyclohexane-1-carboxylate]

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 10 min, 2.) THF, hexane, -78 deg C, 10 min

2: 56 percent / HgCl₂, HClO₄ / a) reflux, 2 h, b) RT, 42 h

With n-butyllithium; perchloric acid; mercury dichloride;
DOI:10.1021/jm970090r