Carbamic acid, N-[(1S)-3-diazo-1-ethyl-2-oxopropyl]-N-methyl-,phenylmethyl ester

Base Information

Chemical Name:Carbamic acid, N-[(1S)-3-diazo-1-ethyl-2-oxopropyl]-N-methyl-,phenylmethyl ester
CAS No.:922705-67-7
Molecular Formula:C14H17N3O3
Molecular Weight:275.307
Hs Code.:

Synonyms:Carbamic acid, N-[(1S)-3-diazo-1-ethyl-2-oxopropyl]-N-methyl-,phenylmethyl ester

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Chemical Property of Carbamic acid, N-[(1S)-3-diazo-1-ethyl-2-oxopropyl]-N-methyl-,phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Carbamic acid, N-[(1S)-3-diazo-1-ethyl-2-oxopropyl]-N-methyl-,phenylmethyl ester

There total 3 articles about Carbamic acid, N-[(1S)-3-diazo-1-ethyl-2-oxopropyl]-N-methyl-,phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 186581-53-3,908094-01-9,334-88-3
diazomethane

: 146087-16-3
(2S)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)butanoic acid

: 922705-67-7
phenylmethyl [(1S)-3-diazo-1-ethyl-2-oxopropyl]methylcarbamate

Guidance literature:: (2S)-2-(methyl{[(phenylmethyl)oxy]carbonyl}amino)butanoic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at -15 ℃; for 0.25h;

diazomethane; In tetrahydrofuran; dichloromethane; at -15 - 20 ℃;
DOI:10.1002/hlca.200690235

Reference yield:

: 42918-86-5,1145-79-5,2900-20-1,20395-87-3
(S)-2-(((benzyloxy)carbonyl)amino)butanoic acid

: 922705-67-7
phenylmethyl [(1S)-3-diazo-1-ethyl-2-oxopropyl]methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: CSA / toluene / Heating

2.1: Et₃SiH; CF₃COOH / CH₂Cl₂

3.1: ClCOOEt; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

3.2: 80 percent / tetrahydrofuran; CH₂Cl₂ / -15 - 20 °C

With 4-methyl-morpholine; triethylsilane; chloroformic acid ethyl ester; trifluoroacetic acid; camphor-10-sulfonic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1002/hlca.200690235

Reference yield:

: 95656-94-3
phenylmethyl (4S)-5-oxo-4-ethyl-1,3-oxazolidine-3-carboxylate

: 922705-67-7
phenylmethyl [(1S)-3-diazo-1-ethyl-2-oxopropyl]methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃SiH; CF₃COOH / CH₂Cl₂

2.1: ClCOOEt; N-methylmorpholine / tetrahydrofuran / 0.25 h / -15 °C

2.2: 80 percent / tetrahydrofuran; CH₂Cl₂ / -15 - 20 °C

With 4-methyl-morpholine; triethylsilane; chloroformic acid ethyl ester; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.200690235