4-Pyridinecarboxylicacid, 2-[(5-chloro-2-hydroxyphenyl)methylene]hydrazide

Base Information

• Chemical Name: 4-Pyridinecarboxylicacid, 2-[(5-chloro-2-hydroxyphenyl)methylene]hydrazide
• CAS No.: 732-92-3
• Molecular Formula: C13H10 Cl N3 O2
• Molecular Weight: 275.694
• Mol file: 732-92-3.mol

Synonyms:4-Pyridinecarboxylicacid, [(5-chloro-2-hydroxyphenyl)methylene]hydrazide (9CI); Isonicotinic acid,(5-chlorosalicylidene)hydrazide (6CI,7CI,8CI); 5-Chlorosalicylaldehydeisonicotinoylhydrazone; NSC 27607

Chemical Property of 4-Pyridinecarboxylicacid, 2-[(5-chloro-2-hydroxyphenyl)methylene]hydrazide

Chemical Property:

• Boiling Point: 384.9°Cat760mmHg
• Flash Point: 186.6°C
• Density: 1.4g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinecarboxylicacid, 2-[(5-chloro-2-hydroxyphenyl)methylene]hydrazide

There total 6 articles about 4-Pyridinecarboxylicacid, 2-[(5-chloro-2-hydroxyphenyl)methylene]hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

isoniazid (54-85-3,7640-37-1) + 5-chlorosalicyclaldehyde (635-93-8) → 5-chlorosalicylaldehyde isonicotinoyl hydrazone (732-92-3)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.bmc.2015.04.040

Reference yield: 91.0%

isoniazid (54-85-3,7640-37-1) + 5-chlorosalicyclaldehyde (635-93-8) → (E)-N'-(5-chloro-2-hydroxybenzaldehyde)isonicotinohydrazide (732-92-3)

Guidance literature:

In methanol; for 3h; Reflux;

DOI:10.1007/s13738-021-02355-0

Reference yield:

pyridine-4-carboxylic acid (55-22-1) → 5-chlorosalicylaldehyde isonicotinoyl hydrazone (732-92-3)

Guidance literature:

Multi-step reaction with 3 steps

1: Amberlyst-15

2: hydrazine hydrate / ethanol / 3 h / Reflux

3: ethanol / Reflux

With hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2015.04.040

upstream raw materials:

isoniazid

5-chlorosalicyclaldehyde

pyridine-4-carboxylic acid

isonicotinic acid ethylester

Downstream raw materials:

RuCl(CO)(P(C₆H₅)3)(C₅H₄NCONHNCHC₆H₃OCl)

RuCl(CO)(As(C₆H₅)3)(C₅H₄NCONHNCHC₆H₃OCl)

Refernces

• 1、 Kargar, Hadi. "Molybdenum(VI) complexes with tridentate Schiff base ligands derived from isoniazid as catalysts for the oxidation of sulfides: synthesis, X-ray crystal structure determination and spectral characterization". . . Retrieved 2021/08/16.
• 2、 Backes, Gregory L.,Jursic, Branko S.,Neumann, Donna M.. "Potent antimicrobial agents against azole-resistant fungi based on pyridinohydrazide and hydrazomethylpyridine structural motifs". . p. 3397 - 3407. Retrieved 2015/08/03.