3,6-DIHYDROXY-2-METHOXY BENZOIC ACID

Base Information

• Chemical Name: 3,6-DIHYDROXY-2-METHOXY BENZOIC ACID
• CAS No.: 118303-91-6
• Molecular Formula: C₈H₈O₅
• Molecular Weight: 184.149
• Mol file: 118303-91-6.mol

Synonyms:3,6-Dihydroxy-2-methoxybenzoicacid; Leiocarpic acid

Chemical Property of 3,6-DIHYDROXY-2-METHOXY BENZOIC ACID

Chemical Property:

• PSA: 86.99000
• LogP: 0.80460

Purity/Quality:

≥99% ^*data from raw suppliers

3,6-Dihydroxy-2-methoxybenzoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6-DIHYDROXY-2-METHOXY BENZOIC ACID

There total 2 articles about 3,6-DIHYDROXY-2-METHOXY BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methoxyhydroquinone (824-46-4) → 3,6-Dihydroxy-2-methoxybenzoic acid (118303-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trichloroacetic acid / CH₂Cl₂ / 96 h / Ambient temperature

trichloroacetic acid; In dichloromethane;

DOI:10.1021/jo00065a015

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 1,4-Bis(1-ethoxyethoxy)-2-methoxybenzene (148460-98-4) → 3,6-Dihydroxy-2-methoxybenzoic acid (118303-91-6)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1021/jo00065a015

Reference yield:

3,6-Dihydroxy-2-methoxybenzoic acid (118303-91-6) → (S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide (125198-28-9)

Guidance literature:

Multi-step reaction with 5 steps

1: aq. NaOH / dimethylformamide / 60 °C

2: aq. NaOH / ethanol; dioxane / 1) 80 deg C, 5 h, 2) rt, overnight

3: SOCl₂, DMF / toluene / 1.5 h / 60 °C

4: CH₂Cl₂

5: 92 percent / H₂ / 5percent Pd/C / ethanol / 1 h / 760 Torr

With sodium hydroxide; thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jo00065a015

upstream raw materials:

carbon dioxide

1,4-Bis(1-ethoxyethoxy)-2-methoxybenzene

methoxyhydroquinone

Downstream raw materials:

(S)-N-<(1-Ethyl-2-pyrrolidinyl)methyl>-5-hydroxy-6-methoxysalicylamide

3,6-bis(benzyloxy)-2-methoxybenzoic acid

(S)-3,6-Bis(benzyloxy)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-2-methoxybenzamide

NCQ 344