Cyclopentanecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinazolinyl)oxy]-, (1R,2R,4R)-

Base Information

Chemical Name:Cyclopentanecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinazolinyl)oxy]-, (1R,2R,4R)-
CAS No.:923274-30-0
Molecular Formula:C30H31N3O7
Molecular Weight:545.592
Hs Code.:

Cyclopentanecarboxylic acid,
2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4-
[(7-methoxy-2-phenyl-4-quinazolinyl)oxy]-, (1R,2R,4R)-

Synonyms:

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Chemical Property of Cyclopentanecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinazolinyl)oxy]-, (1R,2R,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinazolinyl)oxy]-, (1R,2R,4R)-

There total 11 articles about Cyclopentanecarboxylic acid, 2-[[[(1R,2S)-2-ethenyl-1-(ethoxycarbonyl)cyclopropyl]amino]carbonyl]-4- [(7-methoxy-2-phenyl-4-quinazolinyl)oxy]-, (1R,2R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 923274-29-7
(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid tert-butyl ester

: 923274-30-0
(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:: With triethylsilane; trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 862259-02-7
trans-(3R,4R)-3,4-bis(methoxycarbonyl)cyclopentanol

: 923274-30-0
(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide; water / methanol / 4 h / 20 °C

2: pyridine; acetic anhydride / 20 °C

3: boron trifluoride diethyl etherate / dichloromethane / 1.17 h / -10 °C

4: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 0 °C

5: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 0 - 20 °C

7: triethylsilane; trifluorormethanesulfonic acid / dichloromethane / 2 h / 20 °C

With pyridine; triethylsilane; lithium hydroxide; sodium hydroxide; trifluorormethanesulfonic acid; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; water; acetic anhydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 6: Mitsunobu reaction;

Reference yield:

: 862174-60-5
(1R,4R,5R)-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid

: 923274-30-0
(1R,2R,4R)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinazolin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dmap / dichloromethane / 0 - 20 °C

2: lithium hydroxide; water / 1,4-dioxane / 0.75 h / 0 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 2.5 h / 0 - 20 °C

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 12 h / 0 - 20 °C

5: triethylsilane; trifluorormethanesulfonic acid / dichloromethane / 2 h / 20 °C

With triethylsilane; dmap; lithium hydroxide; trifluorormethanesulfonic acid; di-isopropyl azodicarboxylate; water; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 4: Mitsunobu reaction;