Oxazole, 2-(4-methylphenyl)-5-phenyl-

Base Information

• Chemical Name: Oxazole, 2-(4-methylphenyl)-5-phenyl-
• CAS No.: 16155-60-5
• Molecular Formula: C16H13 N O
• Molecular Weight: 235.285
• NSC Number: 90778
• DSSTox Substance ID: DTXSID80293574
• Nikkaji Number: J1.371.808C
• Wikidata: Q82032398
• Mol file: 16155-60-5.mol

Synonyms:5-Phenyl-2-(p-tolyl)oxazole;16155-60-5;oxazole, 2-(4-methylphenyl)-5-phenyl-;NSC90778;Enamine_002047;SCHEMBL4883303;2-(4-tolyl)-5-phenyl-oxazol;DTXSID80293574;HMS1399N01;5-PHENYL-2-P-TOLYLOXAZOLE;NSC-90778;AKOS027328793;CS-0281293;Z56822462

Chemical Property of Oxazole, 2-(4-methylphenyl)-5-phenyl-

Chemical Property:

• Vapor Pressure: 3.93E-06mmHg at 25°C
• Boiling Point: 396.4°Cat760mmHg
• Flash Point: 166.7°C
• Density: 1.108g/cm³
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 235.099714038
• Heavy Atom Count: 18
• Complexity: 254

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=NC=C(O2)C3=CC=CC=C3

Technology Process of Oxazole, 2-(4-methylphenyl)-5-phenyl-

There total 34 articles about Oxazole, 2-(4-methylphenyl)-5-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(p-tolyl)oxazole (62882-04-6) + iodobenzene (591-50-4) → 5-phenyl-2-p-tolyloxazole (16155-60-5)

Guidance literature:

With triphenylphosphine; silver carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dichloromethane; water; at 60 ℃; for 24h;

DOI:10.1039/b719466h

Reference yield: 87.0%

2-aminoacetophenone hydrochloride (5468-37-1) + 4-methyl-benzaldehyde (104-87-0) → 5-phenyl-2-p-tolyloxazole (16155-60-5)

Guidance literature:

With tert.-butylhydroperoxide; iodine; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 70 ℃; for 10h;

DOI:10.1021/ol101596s

Reference yield: 86.0%

p-methylbenzaldehyde oxime (3235-02-7,3717-15-5,3717-16-6,140461-26-3,140461-27-4) + phenylacetylene (536-74-3) → 5-phenyl-2-p-tolyloxazole (16155-60-5)

Guidance literature:

p-methylbenzaldehyde oxime; With trifluorormethanesulfonic acid; silica gel; In toluene; at 50 ℃; for 0.5h;

phenylacetylene; In toluene; at 70 ℃; for 3.5h;

With copper(II) choride dihydrate; lithium chloride hydrate; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; propan-1-ol; toluene; at 60 ℃; for 4h; under 9750.98 Torr;

DOI:10.1002/jhet.1637

upstream raw materials:

(RS)-mandelonitrile

4-methyl-benzaldehyde

4-Methyl-N-[1-(2-oxo-2-phenylethyl)]benzamide

sulfuric acid

Downstream raw materials:

5-phenyl-2-{4-[trans-2-(2-phenyl-benzofuran-6-yl)-vinyl]-phenyl}-oxazole

2-[4-(2-biphenyl-4-yl-vinyl)-phenyl]-5-phenyl-oxazole

2-[4-(trans-2-naphthalen-1-yl-vinyl)-phenyl]-5-phenyl-oxazole

2-[4-(2-naphthalen-2-yl-vinyl)-phenyl]-5-phenyl-oxazole