2-(p-Tolyl)oxazole

Base Information

• Chemical Name: 2-(p-Tolyl)oxazole
• CAS No.: 62882-04-6
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Hs Code.: 2934999090
• European Community (EC) Number: 897-947-2
• DSSTox Substance ID: DTXSID60494880
• Nikkaji Number: J2.589.308E
• Wikidata: Q72495072
• Mol file: 62882-04-6.mol

Synonyms:2-(p-Tolyl)oxazole;62882-04-6;2-(4-methylphenyl)-1,3-oxazole;2-P-TOLYLOXAZOLE;2-(4-methylphenyl)oxazole;Oxazole, 2-(4-methylphenyl);SCHEMBL3031252;DTXSID60494880;WHELBNUVILHIHT-UHFFFAOYSA-N;MFCD15527550;AKOS022358144;AS-38570;AM20040902;CS-0172132;A914768

Chemical Property of 2-(p-Tolyl)oxazole

Chemical Property:

• Boiling Point: 261℃
• Flash Point: 103℃
• PSA: 26.03000
• Density: 1.082
• LogP: 2.65000
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 159.068413911
• Heavy Atom Count: 12
• Complexity: 141

Purity/Quality:

97% ^*data from raw suppliers

2-P-Tolyloxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=NC=CO2

Technology Process of 2-(p-Tolyl)oxazole

There total 8 articles about 2-(p-Tolyl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(4-methylphenyl)-4,5-dihydro-1,3-oxazole (10200-70-1) → 2-(p-tolyl)oxazole (62882-04-6)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 10h; Molecular sieve;

DOI:10.1002/asia.201300267

Reference yield: 88.0%

oxazol (288-42-6) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 2-(p-tolyl)oxazole (62882-04-6)

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); 1,10-Phenanthroline; copper diacetate; sodium carbonate; In 1,4-dioxane; dimethyl sulfoxide; at 20 - 100 ℃; for 4.58333h; Inert atmosphere;

DOI:10.1039/c2ob26270c

Reference yield: 85.1%

p-tolylzinc(II) chloride (90252-89-4) + 2-(methylthio)oxazole (201017-90-5) → 2-(p-tolyl)oxazole (62882-04-6)

Guidance literature:

With bis(triphenylphosphine)nickel(II) chloride; In tetrahydrofuran; at 60 - 65 ℃; for 6h; Inert atmosphere;

DOI:10.1021/ol900260g

upstream raw materials:

oxazol

4-tolyl iodide

p-tolylzinc(II) chloride

2-(methylthio)oxazole

Downstream raw materials:

5-(Pyridine-3-yl)-2-(p-tolyl)oxazole

5-phenyl-2-p-tolyloxazole

5-o-tolyl-2-p-tolyloxazole

5-(4-Chloro-phenyl)-2-p-tolyl-oxazole