Technology Process of 3-Pyridinecarboxylic acid,
2-[(1E,3R)-3-[bis(phenylmethyl)amino]-4-(2-fluorophenyl)-1-buten-1-yl]-
There total 7 articles about 3-Pyridinecarboxylic acid,
2-[(1E,3R)-3-[bis(phenylmethyl)amino]-4-(2-fluorophenyl)-1-buten-1-yl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-[(E)-(R)-3-dibenzylamino-4-(2-fluoro-phenyl)-but-1-enyl]-nicotinic acid methyl ester;
With
lithium hydroxide; water;
In
1,4-dioxane;
for 24h;
With
hydrogenchloride; water;
In
1,4-dioxane;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / acetonitrile / 21 h / 50 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / -10 °C
3.1: pyridiniumsulfonic acid; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.75 h / 10 - 20 °C
4.1: potassium tert-butylate / diethyl ether / 0.5 h / Heating / reflux
4.2: 16 h / -78 - 20 °C
5.1: lithium hydroxide; water / 1,4-dioxane / 24 h
With
lithium hydroxide; lithium aluminium tetrahydride; pyridiniumsulfonic acid; potassium tert-butylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; dimethyl sulfoxide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / diethyl ether / 0.5 h / Heating / reflux
1.2: 16 h / -78 - 20 °C
2.1: lithium hydroxide; water / 1,4-dioxane / 24 h
With
lithium hydroxide; potassium tert-butylate; water;
In
1,4-dioxane; diethyl ether;
![2-[(E)-(R)-3-dibenzylamino-4-(2-fluoro-phenyl)-but-1-enyl]-nicotinic acid methyl ester](/Databaselist/images/loading.webp)
