4-(2-Methoxyphenyl)benzaldehyde

Base Information

• Chemical Name: 4-(2-Methoxyphenyl)benzaldehyde
• CAS No.: 421553-62-0
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Hs Code.: 2913000090
• European Community (EC) Number: 673-306-0
• DSSTox Substance ID: DTXSID90374828
• Nikkaji Number: J2.159.281A
• Wikidata: Q72489354
• Mol file: 421553-62-0.mol

Synonyms:421553-62-0;4-(2-methoxyphenyl)benzaldehyde;2'-Methoxy-[1,1'-biphenyl]-4-carbaldehyde;2'-Methoxy-biphenyl-4-carbaldehyde;2'-Methoxybiphenyl-4-carbaldehyde;2'-Methoxy-biphenyl-4-carboxaldehyde;2'-methoxy-[1,1'-biphenyl]-4-carboxaldehyde;2'-methoxy[1,1'-biphenyl]-4-carbaldehyde;2'-Methoxybiphenyl-4-carboxaldehyde;SCHEMBL2009055;DTXSID90374828;CFGCKFDEJVKBCY-UHFFFAOYSA-N;AR2066;MFCD01631913;AKOS000302941;AS-2083;4-(2-methoxyphenyl)benzaldehyde, AldrichCPR;BB 0222523;CS-0097876;FT-0644598;2'-methoxy[1,1'-biphenyl]-4-carboxaldehyde;EN300-85006;A825794;Z732813184

Chemical Property of 4-(2-Methoxyphenyl)benzaldehyde

Chemical Property:

• Boiling Point: 328.7 °C at 760 mmHg
• Flash Point: 144.6 °C
• PSA: 26.30000
• Density: 1.114g/cm³
• LogP: 3.17470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 212.083729621
• Heavy Atom Count: 16
• Complexity: 219

Purity/Quality:

98%min ^*data from raw suppliers

2''-Methoxy-biphenyl-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C2=CC=C(C=C2)C=O
• Uses: 2''-Methoxy-biphenyl-4-carbaldehyde

Technology Process of 4-(2-Methoxyphenyl)benzaldehyde

There total 9 articles about 4-(2-Methoxyphenyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Methoxyphenylboronic acid (5720-06-9) + 4-bromo-benzaldehyde (1122-91-4) → 2'-methoxy-[1,1'-biphenyl]-4-carboxaldehyde (421553-62-0)

Guidance literature:

With sodium phosphate; palladium on activated charcoal; In water; isopropyl alcohol; at 20 ℃; for 5h;

Reference yield: 95.0%

2-Methoxyphenylboronic acid (5720-06-9) + p-(iodophenyl)carboxaldehyde (15164-44-0) → 2'-methoxy-[1,1'-biphenyl]-4-carboxaldehyde (421553-62-0)

Guidance literature:

With potassium carbonate; In ethanol; water; at 50 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b03480

Reference yield: 89.0%

2-bromoanisole (578-57-4) + 4-formylphenylboronic acid, (87199-17-5) → 2'-methoxy-[1,1'-biphenyl]-4-carboxaldehyde (421553-62-0)

Guidance literature:

With sodium 2-(2-pyridin-3-ylethylamino)ethyl sulfonate; palladium dichloride; In water; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2008.07.101

upstream raw materials:

2-Methoxyphenylboronic acid

4-bromo-benzaldehyde

2-bromoanisole

4-formylphenylboronic acid,

Refernces

• 1、 Cheng, Mu-Jeng,Kardile, Rahul Dadabhau,Kuo, Tung-Chun,Liu, Rai-Shung,More, Sayaji Arjun. "Gold Catalysts Can Generate Nitrone Intermediates from a Nitrosoarene/Alkene Mixture, Enabling Two Distinct Catalytic Reactions: A Nitroso-Activated Cycloheptatriene/Benzylidene Rearrangement". supporting information. p. 5506 - 5511. Retrieved 2021/07/31.
• 2、 Clark, Kyle J.,Ess, Daniel H.,Jensen, Christopher A.,Kenney, Karissa C.,Larson, Alexandra J. S.,Martinez, Erin E.,Michaelis, David J.,Nazari, S. Hadi,Smith, Stacey J.,Valdivia-Berroeta, Gabriel A.. "Monosubstituted, Anionic Imidazolyl Ligands from N?H NHC Precursors and Their Activity in Pd-Catalyzed Cross-Coupling Reactions". supporting information. . Retrieved 2020/07/06.