Tolpadol

Base Information

• Chemical Name: Tolpadol
• CAS No.: 77502-27-3
• Molecular Formula: C28H26 N4 O2
• Molecular Weight: 450.54
• Hs Code.: 2933399090
• Mol file: 77502-27-3.mol

Synonyms:MFA 285;Tolpadol

Chemical Property of Tolpadol

Chemical Property:

• Vapor Pressure: 3.94E-21mmHg at 25°C
• Boiling Point: 729.4°C at 760 mmHg
• Flash Point: 394.9°C
• PSA: 90.96000
• Density: 1.208g/cm³
• LogP: 5.88540

Purity/Quality:

99% ^*data from raw suppliers

TOLPADOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tolpadol

There total 7 articles about Tolpadol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Methyl-N-(1-oxy-pyridin-4-ylmethyl)-benzamide (77502-43-3) + 2-Methyl-N-pyridin-4-ylmethyl-benzamide (64095-81-4) → N,N'-di(2-methylbenzoyl)-1,2-di(4-pyridyl)ethylenediamine (77502-27-3)

Guidance literature:

With acetic anhydride; at 70 ℃; for 3h;

DOI:10.1002/jhet.5570200658

Reference yield: 39.0%

2-Methyl-N-(1-oxy-pyridin-4-ylmethyl)-benzamide (77502-43-3) → N,N'-di(2-methylbenzoyl)-1,2-di(4-pyridyl)ethylenediamine (77502-27-3)

Guidance literature:

In acetic anhydride; at 140 ℃; for 1.5h;

DOI:10.1002/jhet.5570180707

Reference yield: 21.0%

2-Methyl-N-(1-oxy-pyridin-4-ylmethyl)-benzamide (77502-43-3) → (E)-ethyl 2-cyano-3-(4-pyridyl)-3-(2-methylbenzoylamino)acrylate (108462-90-4) + N,N'-di(2-methylbenzoyl)-1,2-di(4-pyridyl)ethylenediamine (77502-27-3)

Guidance literature:

With acetic anhydride; ethyl 2-cyanoacetate; at 100 ℃; for 2h;

upstream raw materials:

2-Methyl-N-(1-oxy-pyridin-4-ylmethyl)-benzamide

2-Methyl-N-pyridin-4-ylmethyl-benzamide

ethyl 2-cyanoacetate

ortho-methylbenzoic acid

Downstream raw materials:

ortho-methylbenzoic acid

2-(2-methylphenyl)-4,5-di(4-pyridyl)-2-imidazoline