2-methyl-N-(pyridin-4-ylmethyl)benzamide

Base Information

• Chemical Name: 2-methyl-N-(pyridin-4-ylmethyl)benzamide
• CAS No.: 64095-81-4
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.278
• DSSTox Substance ID: DTXSID90349612
• Nikkaji Number: J284.965H
• Wikidata: Q82125014
• ChEMBL ID: CHEMBL1502383
• Mol file: 64095-81-4.mol

Synonyms:2-methyl-N-(pyridin-4-ylmethyl)benzamide;MLS000031201;HMS2291I07;64095-81-4;Oprea1_058693;Oprea1_246428;CHEMBL1502383;SCHEMBL13161957;DTXSID90349612;STK053731;AKOS001199262;2-Methyl-N-pyridin-4-ylmethyl-benzamide;SMR000009626;SR-01000528169;2-METHYL-N-[(PYRIDIN-4-YL)METHYL]BENZAMIDE;SR-01000528169-1;Z30168696

Chemical Property of 2-methyl-N-(pyridin-4-ylmethyl)benzamide

Chemical Property:

• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 226.110613074
• Heavy Atom Count: 17
• Complexity: 249

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C(=O)NCC2=CC=NC=C2

Technology Process of 2-methyl-N-(pyridin-4-ylmethyl)benzamide

There total 1 articles about 2-methyl-N-(pyridin-4-ylmethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ortho-methylbenzoic acid (118-90-1) + 4-(aminomethyl)pyridine (3731-53-1) → 2-Methyl-N-pyridin-4-ylmethyl-benzamide (64095-81-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In acetonitrile; for 24h; Ambient temperature;

DOI:10.1002/jhet.5570180707

Reference yield: 95.0%

2-Methyl-N-(1-oxy-pyridin-4-ylmethyl)-benzamide (77502-43-3) + 2-Methyl-N-pyridin-4-ylmethyl-benzamide (64095-81-4) → N,N'-di(2-methylbenzoyl)-1,2-di(4-pyridyl)ethylenediamine (77502-27-3)

Guidance literature:

With acetic anhydride; at 70 ℃; for 3h;

DOI:10.1002/jhet.5570200658

Reference yield: 90.0%

chloroformic acid ethyl ester (541-41-3) + 2-Methyl-N-pyridin-4-ylmethyl-benzamide (64095-81-4) → N-(1,4-dihydropyridylmethylen-1-ethoxycarbonyl)-2-methylbenzamide

Guidance literature:

With triethylamine; In acetone; at -10 ℃; for 1h;

DOI:10.1016/S0040-4020(01)89622-8

upstream raw materials:

ortho-methylbenzoic acid

4-(aminomethyl)pyridine

Downstream raw materials:

N,N'-di(2-methylbenzoyl)-1,2-di(4-pyridyl)ethylenediamine

2-Methyl-N-(1-oxy-pyridin-4-ylmethyl)-benzamide

5-(2-methylphenyl)-3-(4-pyridyl)-1,2,4-oxadiazole