Zoliprofen

Base Information

Chemical Name:Zoliprofen
CAS No.:56355-17-0
Molecular Formula:C₁₂H₁₁NO₃S
Molecular Weight:249.29
Hs Code.:
UNII:J2GC047H27
DSSTox Substance ID:DTXSID10866553
Nikkaji Number:J23.745K
Wikidata:Q27281063
NCI Thesaurus Code:C66706
ChEMBL ID:CHEMBL2107544

Synonyms:2-(4-(2-thiazolyloxy)phenyl)-2-methylacetic acid;480156 S;480156-S;480156S

Suppliers and Price of Zoliprofen

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ZOLIPROFEN 95.00%
5MG
$ 501.42

Total 0 raw suppliers

Chemical Property of Zoliprofen

Chemical Property:

Vapor Pressure:1.31E-07mmHg at 25°C
Boiling Point:414.4°Cat760mmHg
Flash Point:204.4°C
PSA：87.66000
Density:1.33g/cm³
LogP:3.12350
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:249.04596439
Heavy Atom Count:17
Complexity:267

Purity/Quality:: ZOLIPROFEN 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=C(C=C1)OC2=NC=CS2)C(=O)O
Therapeutic Function Antiinflammatory, Analgesic

Technology Process of Zoliprofen

There total 6 articles about Zoliprofen which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56355-16-9
ethyl 2-[4-(2-thiazolyloxy)-phenyl]propionate

: 56355-17-0
2-[4-(2-thiazolyloxy)phenyl]propionic acid

Guidance literature:: With potassium carbonate; In methanol; water; Yield given; Heating;
DOI:10.1248/cpb.31.3424

Reference yield:

: 61881-50-3
amino-4-phenyl methyl malonate d'ethyle

: 56355-17-0
2-[4-(2-thiazolyloxy)phenyl]propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaNO₂, H₂O/7.3percent H₂SO₄ / 1.) 0 deg C, 2 h; 2.) toluene, reflux, 15 min

2: 5.5 g / triethylamine / diethyl ether / 2 h / -10 °C

3: H₂S/triethylamine / diethyl ether / 0.83 h / Ambient temperature

4: 85.3 percent / p-toluenesulfonic acid / acetic acid / 1.5 h / 90 - 95 °C

5: K₂CO₃ / methanol; H₂O / Heating

With sulfuric acid; hydrogen sulfide; water; potassium carbonate; toluene-4-sulfonic acid; triethylamine; sodium nitrite; In methanol; diethyl ether; water; acetic acid;
DOI:10.1248/cpb.31.3424

Reference yield:

: 76510-82-2
diethyl (4-hydroxyphenyl)methylmalonate

: 56355-17-0
2-[4-(2-thiazolyloxy)phenyl]propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 5.5 g / triethylamine / diethyl ether / 2 h / -10 °C

2: H₂S/triethylamine / diethyl ether / 0.83 h / Ambient temperature

3: 85.3 percent / p-toluenesulfonic acid / acetic acid / 1.5 h / 90 - 95 °C

4: K₂CO₃ / methanol; H₂O / Heating

With hydrogen sulfide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In methanol; diethyl ether; water; acetic acid;
DOI:10.1248/cpb.31.3424