R-(+)-Hyoscyamine

Base Information

• Chemical Name: R-(+)-Hyoscyamine
• CAS No.: 13269-35-7
• Molecular Formula: C17H23 N O3
• Molecular Weight: 289.375
• Hs Code.: 2918199090
• Mol file: 13269-35-7.mol

Synonyms:Benzeneaceticacid, a-(hydroxymethyl)-,8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, [3(R)-endo]-; (+)-Atropine;(+)-Hyoscyamine; (R)-Atropine; D-Hyoscyamine; R-(+)-Hyoscyamine; d-Atropine;d-Hyoscyamine

Chemical Property of R-(+)-Hyoscyamine

Chemical Property:

• Vapor Pressure: 3.76E-08mmHg at 25°C
• Melting Point: 106 °C
• Boiling Point: 429.8°Cat760mmHg
• PKA: 14.12±0.10(Predicted)
• Flash Point: 213.7°C
• PSA: 49.77000
• Density: 1.19g/cm³
• LogP: 1.86880

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-Hyoscyamine is similar to L-Hyoscyamine (H674300), a natural compound that has inhibitory activity against cholinesterases. D-Hyoscyamine can be synthesized from Atropine (A794630).

Technology Process of R-(+)-Hyoscyamine

There total 13 articles about R-(+)-Hyoscyamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Atropine (51-55-8) → (+)-Atropine (13269-35-7) + Hyoscyamine (101-31-5)

Guidance literature:

With β?cyclodextrin sulfonic acid; In aq. phosphate buffer; at 25 ℃; pH=3; pH-value; Reagent/catalyst; Resolution of racemate;

DOI:10.1002/chir.22731

Reference yield:

atropine sulfate (5908-99-6,55-48-1,300-40-3,620-61-1,1867-24-9,2472-17-5,2623-69-0,14844-27-0) → (+)-Atropine (13269-35-7) + Hyoscyamine (101-31-5)

Guidance literature:

With triethylamine; In aq. phosphate buffer; acetonitrile; at 10 ℃; pH=7.0; pH-value; Reagent/catalyst; Solvent; Temperature; Thermodynamic data; Resolution of racemate;

DOI:10.1002/chir.22536

Reference yield:

atropine (51-55-8) → (+)-Atropine (13269-35-7) + Hyoscyamine (101-31-5)

Guidance literature:

resolving agent: trans-cellulose tris(4-phenylazophenylcarbamate) ( CPAPC ) adsorbed on silica gel; optical resolution degree examined by HPLC on cis/trans-CPAPC;

DOI:10.1246/cl.1986.983

upstream raw materials:

(1S)-10-camphorsulfonic acid

atropine

3-tropanol

atropine sulfate

Refernces

• 1、 Zaazaa, Hala E.,Salama, Nahla N.,Abd El Halim, Lobna M.,Salem, Maissa Y.,Abd El Fattah, Laila E.. "Strategy Approach for Direct Enantioseparation of Hyoscyamine Sulfate and Zopiclone on a Chiral αl-Acid Glycoprotein Column and Determination of Their Eutomers: Thermodynamic Study of Complexation". . p. 49 - 57. Retrieved 2016/02/20.
• 2、 Okamoto, Yoshio,Sakamoto, Hideaki,Hatada, Koichi,Irie, Masahiro. "RESOLUTION OF ENANTIOMERS BY HPLC ON CELLULOSE TRANS- AND CIS-TRIS(4-PHENYLAZOPHENYLCARBAMATE)". . p. 983 - 986. Retrieved 2007/10/02.