1-Chloro-6-Methoxy-7-broMoisoquinoline

Base Information

• Chemical Name: 1-Chloro-6-Methoxy-7-broMoisoquinoline
• CAS No.: 924271-35-2
• Molecular Formula: C₁₀H₇BrClNO
• Molecular Weight: 272.529
• Hs Code.: 2933499090
• Mol file: 924271-35-2.mol

Synonyms:Isoquinoline,7-bromo-1-chloro-6-methoxy;

Chemical Property of 1-Chloro-6-Methoxy-7-broMoisoquinoline

Chemical Property:

• PSA: 22.12000
• LogP: 3.65930

Purity/Quality:

98%Min ^*data from raw suppliers

7-BROMO-1-CHLORO-6-METHOXYISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Chloro-6-Methoxy-7-broMoisoquinoline

There total 3 articles about 1-Chloro-6-Methoxy-7-broMoisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-bromo-6-methoxyisoquinolin-1(2H)-one (924271-34-1) → 7-bromo-1-chloro-6-methoxyisoquinoline (924271-35-2)

Guidance literature:

7-bromo-6-methoxyisoquinolin-1(2H)-one; With trichlorophosphate; for 2h; Heating / reflux;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

1-bromo-4-iodo-2-methoxybenzene (755027-18-0) → 7-bromo-1-chloro-6-methoxyisoquinoline (924271-35-2)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium diacetate / acetonitrile / 0.67 h / 90 °C

2: diphenylphosphoranyl azide; triethylamine / benzene; Diphenylmethane / 20 - 250 °C

3: trichlorophosphate / 2 h / Reflux

With diphenylphosphoranyl azide; palladium diacetate; triethylamine; trichlorophosphate; In Diphenylmethane; acetonitrile; benzene;

Reference yield:

(2E)-3-(4-bromo-3-methoxyphenyl)acrylic acid (924271-33-0) → 7-bromo-1-chloro-6-methoxyisoquinoline (924271-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenylphosphoranyl azide; triethylamine / benzene; Diphenylmethane / 20 - 250 °C

2: trichlorophosphate / 2 h / Reflux

With diphenylphosphoranyl azide; triethylamine; trichlorophosphate; In Diphenylmethane; benzene;

upstream raw materials:

7-bromo-6-methoxyisoquinolin-1(2H)-one

1-bromo-4-iodo-2-methoxybenzene

(2E)-3-(4-bromo-3-methoxyphenyl)acrylic acid