755027-18-0

Basic information

• Product Name: 2-BROMO-5-IODOANISOLE
• Synonyms: 2-BROMO-5-IODOANISOLE;Benzene, 1-broMo-4-iodo-2-Methoxy-;1-Bromo-4-iodo-2-methoxybenzene, 2-Bromo-5-iodophenyl methyl ether;2-BroMo-5-iodophenyl Methyl ether
• CAS NO: 755027-18-0
• Molecular Formula: C₇H₆BrIO
• Molecular Weight: 312.93
• Product Categories: Aromatic Halides (substituted);Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;Iodine Compounds
• Mol File: 755027-18-0.mol

Chemical Properties

• Boiling Point: 293.7 °C at 760 mmHg
• Flash Point: 131.4 °C
• Appearance: /
• Density: 2.062
• Storage Temp.: Refrigerated.
• CAS DataBase Reference: 2-BROMO-5-IODOANISOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-5-IODOANISOLE(755027-18-0)
• EPA Substance Registry System: 2-BROMO-5-IODOANISOLE(755027-18-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 755027-18-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2-Bromo-5-iodoanisole is used as a reagent in organic synthesis for the preparation of various organic compounds. Its bromine and iodine substituents make it a valuable building block for the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
2-Bromo-5-iodoanisole is used as an intermediate in the production of various pharmaceuticals. Its unique structure and functional groups contribute to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Bromo-5-iodoanisole is utilized as an intermediate for the synthesis of agrochemicals, such as pesticides and herbicides. Its properties enable the creation of effective and targeted agrochemicals for crop protection.
Used in Fine Chemicals Production:
2-Bromo-5-iodoanisole is employed in the production of other fine chemicals, including fragrances, dyes, and specialty chemicals. Its versatility allows for the development of a wide range of high-value products.
Used in Advanced Materials Preparation:
2-Bromo-5-iodoanisole is also used in the preparation of advanced materials, such as polymers, coatings, and sensors. Its unique properties contribute to the development of innovative materials with improved performance and functionality.
Used in Research and Development:
2-Bromo-5-iodoanisole plays a significant role in research and development in the field of organic chemistry. It serves as a valuable tool for exploring new reaction pathways, understanding molecular interactions, and discovering novel applications in various industries.

Upstream product

• 932372-99-1 2-bromo-5-iodophenol 
• 77-78-1 dimethyl sulfate 
• 89942-34-7 2-methoxy-4-iodobenzoic acid 
• 19056-40-7 4-bromo-3-methoxyaniline 

Downstream Products

• 43192-34-3 4-bromo-3-methoxybenzaldehyde 
• 1025369-59-8 2-amino-4'-bromo-3'-methoxybiphenyl-4-carbonitrile 
• 1160360-15-5 C₁₈H₂₇BrO₂Si 
• 1103535-39-2 3-(4-bromo-3-methoxyphenyl)thiophene-2-carboxylic acid 
• 1103535-36-9 ethyl 2-(4-bromo-3-methoxyphenyl)cyclohex-1-ene-1-carboxylate 
• 1313809-06-1 C₃₈H₆₆OSi₂ 
• 1313809-07-2 C₃₅H₅₈OSi 
• 1261500-31-5 ethyl 2-(4-bromo-3-methoxyphenyl)acetate 
• 1562339-31-4 (4-(1H-imidazol-1-yl)-2-methoxyphenyl)boronic acid 
• 924271-34-1 7-bromo-6-methoxyisoquinolin-1(2H)-one 
• 924271-35-2 7-bromo-1-chloro-6-methoxyisoquinoline 
• 113150-38-2 1-Bromo-2-methoxy-4-vinyl-benzene 

Relevant articles and documents

Using Nature's polyenes as templates: studies of synthetic xanthomonadin analogues and realising their potential as antioxidants

Two truncated analogues of the polyenyl photoprotective xanthomonadin pigments have been synthesised utilising an iterative Heck-Mizoroki (HM)/iododeboronation cross coupling approach and investigated as models of the natural product photoprotective agent

Active Molybdenum-Based Anode for Dehydrogenative Coupling Reactions

A new and powerful active anode system that can be operated in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) has been discovered. In HFIP the molybdenum anode forms a compact, conductive, and electroactive layer of higher-valent molybdenum species. This system can replace powerful but stoichiometrically required MoV reagents for the dehydrogenative coupling of aryls. This electrolytic reaction is more sustainable and allows the conversion of a broad scope of activated arenes.

Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

Methods for the conversion of aliphatic acids to alkyl halides have progressed significantly over the past century, however, the analogous decarboxylative bromination of aromatic acids has remained a longstanding challenge. The development of efficient methods for the synthesis of aryl bromides is of great importance as they are versatile reagents in synthesis and are present in many functional molecules. Herein we report a transition metal-free decarboxylative bromination of aromatic acids. The reaction is applicable to many electron-rich aromatic and heteroaromatic acids which have previously proved poor substrates for Hunsdiecker-type reactions. In addition, our preliminary mechanistic study suggests that radical intermediates are not involved in this reaction, which is in contrast to classical Hunsdiecker-type reactivity. Overall, the process demonstrates a useful method for producing valuable reagents from inexpensive and abundant starting materials.

Approaches to Styrenyl Building Blocks for the Synthesis of Polyene Xanthomonadin and its Analogues

A number of aryl building blocks for the synthesis of two xanthomonadin natural product pigments, as well as a related analogue, were accessed using a divergent hydroboration/bromoboration approach from a key alkynyl intermediate. A new approach towards s

Progress Toward a Semi-Synthetic Organism with an Unrestricted Expanded Genetic Alphabet

We have developed a family of unnatural base pairs (UBPs), exemplified by the pair formed between dNaM and dTPT3, for which pairing is mediated not by complementary hydrogen bonding but by hydrophobic and packing forces. These UBPs enabled the creation of

Macrocyclic Compounds As Antiviral Agents

A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):

HCV NS3 PROTEASE INHIBITORS

The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

SULFONAMIDE DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY

A sulfonamide derivative having DP receptor antagonistic activity; and a medicinal composition and a therapeutic agent for allergic diseases which each contains the compound as an active ingredient. The derivative is a compound represented by the general formula (II): (II) (wherein ring A is an aromatic carbocycle, etc.; ring B is a nitrogenous nonaromatic heterocycle, etc.; ring C is an aromatic carbocycle, etc.; R1 is carboxy, etc.; R2's each independently is halogeno, etc.; R3 is optionally substituted alkyloxy, etc.; R4's each independently is halogeno, etc.; R5's each independently is optionally substituted alkyl, etc.; M is sulfonyl, etc.; Y is a single bond, etc.; L1 is a single bond, etc.; L2 is a single bond, etc.; k is 0, 1, 2, 3, or 4; n is 0, 1, or 2; and q is 0, 1, 2, or 3, provided that, for example, a) when ring B is a 6-membered nitrogenous heterocycle containing one or two nitrogen atoms and ring C is a benzene ring, then k is not 0), a pharmaceutically acceptable salt of the compound, or a hydrate of either.

Halogen-lithium exchange between substituted dihalobenzenes and butyllithium: Application to the regioselective synthesis of functionalized bromobenzaldehydes

Halogen-lithium interconversion reactions between unsymmetrically substituted mono- and bifunctional dihalobenzenes C6H 3XHal2 and C6H2XYHal2 (Hal=Br, I; X, Y=F, OR, CF3, CH(OMe)2) and butyllithium were investigated. The resultant organolithium intermediates were converted into the corresponding benzaldehydes in moderate to good yields. As a rule, bromine atoms in the position ortho to the functional group were replaced preferentially with lithium. Intramolecular competition experiments with bifunctional systems revealed that fluorine is capable of activating the neighboring bromine atom more strongly than methoxy and dimethoxymethyl groups. On the replacement of the non-activated bromine with iodine a complete reversal of this reactivity pattern can be accomplished due to the preferred iodine-lithium exchange.

HETEROCYCLIC KINASE INHIBITORS

Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.