2-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-4-yl)sulfanyl]benzoic acid

Base Information

Chemical Name:2-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-4-yl)sulfanyl]benzoic acid
CAS No.:92461-32-0
Molecular Formula:C15H9NO4S
Molecular Weight:299.307
Hs Code.:
DSSTox Substance ID:DTXSID80569483
Wikidata:Q82456643

Synonyms:92461-32-0;2-((1,3-Dioxoisoindolin-4-yl)thio)benzoic acid;SCHEMBL10498838;DTXSID80569483;ZMIQZMJLQSEOJX-UHFFFAOYSA-N;3-(2-carboxyphenylthio)-phthalimide;2-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-4-yl)sulfanyl]benzoic acid

Suppliers and Price of 2-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-4-yl)sulfanyl]benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-4-yl)sulfanyl]benzoic acid

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:299.02522894
Heavy Atom Count:21
Complexity:467

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(=O)O)SC2=CC=CC3=C2C(=O)NC3=O

Technology Process of 2-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-4-yl)sulfanyl]benzoic acid

There total 2 articles about 2-[(1,3-Dioxo-2,3-dihydro-1H-isoindol-4-yl)sulfanyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.4%

: 603-62-3
4-nitro-1H-isoindole-1,3(2H)-dione

: 147-93-3
Thiosalicylic acid

: 92461-32-0
2-<(2,3-Dihydro-1,3-dioxo-1H-isoindol-4-yl)thio>benzoic Acid

Guidance literature:: Thiosalicylic acid; With sodium hydroxide; In water; Heating;

4-nitro-1H-isoindole-1,3(2H)-dione; In N,N-dimethyl-formamide; at 80 ℃; for 8h;
DOI:10.1016/j.cclet.2014.05.031

Reference yield: 81.0%

: 603-62-3
4-nitro-1H-isoindole-1,3(2H)-dione

: 134-23-6,19296-18-5
2-sulfanylbenzoic acid, disodium salt

: 92461-32-0
2-<(2,3-Dihydro-1,3-dioxo-1H-isoindol-4-yl)thio>benzoic Acid

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 8h;
DOI:10.1002/hlca.19910740521

Reference yield:

: 92461-32-0
2-<(2,3-Dihydro-1,3-dioxo-1H-isoindol-4-yl)thio>benzoic Acid

: 4-((1,3,6-trioxothiochromeno[2,3-e]isoindol-2(1H,3H,6H)-yl)methyl)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: polyphosphoric acid / 1.5 h / 150 °C

2: sodium hydroxide / water / 1.5 h / Reflux

3: acetic anhydride / 5,5-dimethyl-1,3-cyclohexadiene / 1.5 h / Reflux

4: acetic acid / 3 h / Reflux

With acetic anhydride; acetic acid; sodium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene; water;
DOI:10.1016/j.cclet.2014.05.031