Fosamprenavir

Base Information

Chemical Name:Fosamprenavir
CAS No.:226700-79-4
Molecular Formula:C₂₅H₃₆N₃O₉PS
Molecular Weight:585.615
Hs Code.:
UNII:WOU1621EEG
DSSTox Substance ID:DTXSID2048296,DTXSID20861514
Nikkaji Number:J1.972.383F
Wikipedia:Fosamprenavir
Wikidata:Q1385311
NCI Thesaurus Code:C83720
Metabolomics Workbench ID:43490
ChEMBL ID:CHEMBL1664
Mol file:226700-79-4.mol

Synonyms:(3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-1-(phenylmethyl)-2-(phosphonooxy)propyl)carbamic acid C-(tetrahydro-3-furanyl) ester;fos-amprenavir;fosamprenavir;fosamprenavir calcium;fosamprenavir sodium;GW 433908;GW 433908A;GW 433908G;GW 908;GW-433908;GW-433908A;GW-433908G;GW-908;GW433908;GW433908G;Lexiva;Telzir;VX 175;VX-175

Suppliers and Price of Fosamprenavir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Fosamprenavir >98%
250 mg
$ 1300.00

American Custom Chemicals Corporation
FOSAMPRENAVIR 95.00%
100MG
$ 7309.00

American Custom Chemicals Corporation
FOSAMPRENAVIR 95.00%
10MG
$ 1955.73

Total 27 raw suppliers

Chemical Property of Fosamprenavir

Chemical Property:

Refractive Index:1.611
PKA:1.77±0.10(Predicted)
PSA：195.91000
Density:1.4 g/cm³
LogP:4.57270
XLogP3:1.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:14
Exact Mass:585.19098791
Heavy Atom Count:39
Complexity:912

Purity/Quality:

97% ^*data from raw suppliers

Fosamprenavir >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2CCOC2)OP(=O)(O)O)S(=O)(=O)C3=CC=C(C=C3)N
Isomeric SMILES:CC(C)CN(C[C@H]([C@H](CC1=CC=CC=C1)NC(=O)O[C@H]2CCOC2)OP(=O)(O)O)S(=O)(=O)C3=CC=C(C=C3)N
Recent ClinicalTrials:Using Drug Levels and Drug Resistance Testing to Select Effective Anti-HIV Drug Combinations in Patients With Drug-resistant HIV
Recent EU Clinical Trials:Raltegravir-based regimen versus raltegravir-based regimen plus atorvastatin for reducing ?inflamaging? (aging-related complication) in HIV-infected patients older than 60 years.

Technology Process of Fosamprenavir

There total 6 articles about Fosamprenavir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333313-45-3
(S)-tetrahydrofuran-3-yl (2S,3R)-4-(4-(1,3-dioxoisoindolin-2-yl)-N-isobutylphenylsulfonamido)-1-phenyl-3-(phosphonooxy)-butan-2-ylcarbamate

: 226700-79-4
fosamprenavir

Guidance literature:: With methanol; methylamine; at 45 - 50 ℃;

Reference yield:

: 1333313-44-2
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride

: 226700-79-4
fosamprenavir

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethyl acetate / 20 °C

1.2: Reflux

2.1: pyridine; trichlorophosphate / 0 - 20 °C

2.2: 0 - 5 °C

3.1: methylamine; methanol / 45 - 50 °C

With pyridine; methanol; methylamine; trichlorophosphate; In ethyl acetate;

Reference yield:

: 160232-08-6
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol

: 226700-79-4
fosamprenavir

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / toluene / 20 - 35 °C

1.2: 1.5 h / 75 - 80 °C

2.1: ethyl acetate / 20 °C

2.2: Reflux

3.1: pyridine; trichlorophosphate / 0 - 20 °C

3.2: 0 - 5 °C

4.1: methylamine; methanol / 45 - 50 °C

With pyridine; methanol; dmap; triethylamine; methylamine; trichlorophosphate; In ethyl acetate; toluene;