N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride

Base Information

Chemical Name:N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride
CAS No.:1333313-44-2
Molecular Formula:C₂₈H₃₁N₃O₅S*ClH
Molecular Weight:558.098
Hs Code.:

Synonyms:N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride

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Chemical Property of N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride

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Technology Process of N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride

There total 2 articles about N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4435-59-0
4-(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)-1-benzenesulfonyl chloride

: 160232-08-6
(2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol

: 1333313-44-2
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride

Guidance literature:: 4-(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)-1-benzenesulfonyl chloride; (2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol; With dmap; triethylamine; In toluene; at 20 - 35 ℃;

With hydrogenchloride; In water; isopropyl alcohol; at 75 - 80 ℃; for 1.5h; Product distribution / selectivity;

Reference yield:

: 98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

: 1333313-44-2
N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-4-(1,3-dioxoisoindolin-2-yl)-N-isobutylbenzenesulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol / 3 h / Reflux

2.1: dmap; triethylamine / toluene / 20 - 35 °C

2.2: 1.5 h / 75 - 80 °C

With dmap; triethylamine; In methanol; toluene;