Chemical Property of Follicle stimulating hormone
Chemical Property:
- PSA：0.00000
- LogP:0.00000
- Storage Temp.:2-8°C
- Solubility.:H2O: 50 mg/mL, soluble
- Purity/Quality:
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98%,99%, *data from raw suppliers
Follicle Stimulating Hormone, Human *data from reagent suppliers
Safty Information:
- Pictogram(s):
B
- Hazard Codes:B
- Safety Statements:
22-24/25
- MSDS Files:
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Total 1 MSDS from other Authors
Useful:
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Description
Gonal-F was launched in Austria, Germany, Denmark, Ireland, Italy,
Norway, Sweden, Switzerland, France and the UK for the treatment of infertility. The
recombinant follicule stimulating hormone (recFSH) was produced by introducing the
genes for the α- and β-FSH subunits into the genome of Chinese hamster ovary cells.
The isolated recFSH was a glycosylated bioactive dimer that appeared to be identical
to urinary human FSH. Biochemically, the recFSH was equal to or slightly better to
the uroFSH. The ultra-high purity of recFSH makes it less prone to side effects from
contaminants in uroFSH and can be injectable. Puregon was launched in Denmark, Germany and the UK for ovulation
induction in clomiphene-resistent anovulation and controlled ovarian
hyperstimulation. Transfected Chinese hamster ovary cells with plasmids containing
the genes encoding the α- and β-FSH subunits produced recFSH that was similar to
uroFSH. In both cases (follitropin α and β) no antibody formation was detected,
however, this form appeared to be more active than follitropin α in that there was a
25% greater pregnancy rate compared to uroFSH.
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Uses
A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consi Follicle stimulating hormone (FSH) from human pituitary has been used for-in vitro luteinization of Macaque granulosa cellsluteal cell proliferation assayculturing of preantral follicle cells obtained from micein vitro maturation of immature cumulus-oocyte complexes (COCs) obtained from mice andculture of RAW264.7 cell line Recombinant human FSH is used for the treatment of
infertility and to stimulate follicular development.
Recently, it has been well known that the majority of
gonadotroph adenomas are clinically silent/nonfunctioning and difficult to identify. They are poorly differentiated and produce and secrete hormones inefficiently.
These hormones include FSH β-, LH β-, and GPH
α-subunits.
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Biological Functions
Follitropins are hormonal products that consist entirely of FSH and are used to stimulate ovarian
follicle growth in women who do not have primary ovarian failure. In the absence of an adequate
endogenous LH surge, however, hCG must be given following the use of follitropins to stimulate
ovulation.
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Clinical Use
The gonadotropin follicle-stimulating hormones (FSH), follitropin alfa (Gonal-F) and follitropin beta (Follistim), are produced in the anterior lobe of the pituitary gland. FSH can function in two ways. On the one hand, it causes increased spermatogenesis in men. On the other hand, in concert with estrogen and luteinizing hormone (LH), it stimulates follicular growth and development in women. Consequently, FSH may be useful in the treatment of infertility. FSH is a member of a superfamily of proteins, all structurally related, which includes LH, chorionic gonadotropin, and thyroid-stimulating hormone (TSH).
