2-(1-Methyl-1H-pyrazol-5-yl)ethanol

Base Information

• Chemical Name: 2-(1-Methyl-1H-pyrazol-5-yl)ethanol
• CAS No.: 924911-13-7
• Molecular Formula: C6H10N2O
• Molecular Weight: 126.158
• Mol file: 924911-13-7.mol

Synonyms:2-(2-methyl-2H-pyrazol-3-yl)-ethanol;5-(2-hydroxy-5-nitrophenyl)-1-methylpyrazole;2-(2-methyl-2H-pyrazol-3-yl)-4-nitro-phenol;

Chemical Property of 2-(1-Methyl-1H-pyrazol-5-yl)ethanol

Chemical Property:

• PSA: 38.05000
• LogP: -0.04510

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(1-Methyl-1H-pyrazol-5-yl)ethan-1-ol 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1-Methyl-1H-pyrazol-5-yl)ethanol

There total 3 articles about 2-(1-Methyl-1H-pyrazol-5-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

oxirane (75-21-8,99932-75-9) + 1-methyl-1H-pyrazole (930-36-9) → 2-(1-methyl-1H-pyrazol-5-yl)ethan-1-ol (924911-13-7)

Guidance literature:

1-methyl-1H-pyrazole; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 - -10 ℃; Inert atmosphere;

oxirane; In tetrahydrofuran; hexanes; at -10 - 25 ℃;

With water; ammonium chloride; In tetrahydrofuran; hexanes; at 18 - 25 ℃;

Reference yield: 61.0%

5-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-1-methyl-1H-pyrazole (924911-12-6) → 2-(1-methyl-1H-pyrazol-5-yl)ethan-1-ol (924911-13-7)

Guidance literature:

With water; hydrogen bromide; sodium fluoride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

1-methyl-1H-pyrazole (930-36-9) + ethyleneglycol sulfate (1072-53-3) → 2-(1-methyl-1H-pyrazol-5-yl)ethan-1-ol (924911-13-7)

Guidance literature:

1-methyl-1H-pyrazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃;

ethyleneglycol sulfate; In tetrahydrofuran; hexane; at 20 ℃; for 48h;

With sulfuric acid; In tetrahydrofuran; hexane; for 16h; Further stages.; Heating;

DOI:10.1055/s-2008-1067021

upstream raw materials:

5-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)-1-methyl-1H-pyrazole

1-methyl-1H-pyrazole

ethyleneglycol sulfate

oxirane

Downstream raw materials:

toluene-4-sulfonic acid 2-(2-methyl-2H-pyrazol-3-yl)-ethyl ester

1-methyl-4-phenyl-1,4,6,7-tetrahydropyrano[4,3-c]pyrazole

6-[4-[4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl]piperazin-1-yl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine

4-{4-[2-(1-methyl-1H-pyrazol-5-yl)ethoxy]phenyl}-1-[3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-ol

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