4-AMINO-2-METHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: 4-AMINO-2-METHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID HYDROCHLORIDE
• CAS No.: 92534-70-8
• Molecular Formula: C₅H₇N₃O₂*ClH
• Molecular Weight: 177.59
• Hs Code.: 2933199090
• Mol file: 92534-70-8.mol

Synonyms:4-Amino-1-methylisoquinoline;4-amino-1-methylpyrazole-5-carboxylic acid hydrochloride;

Chemical Property of 4-AMINO-2-METHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID HYDROCHLORIDE

Chemical Property:

• PSA: 81.14000
• LogP: 1.08370
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-2-methyl-2H-pyrazole-3-carboxylicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMINO-2-METHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID HYDROCHLORIDE

There total 3 articles about 4-AMINO-2-METHYL-2 H-PYRAZOLE-3-CARBOXYLIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-methyl-4-nitro-1H-pyrazole-5-carboxylic acid (92534-69-5) → 4-amino-1-methylpyrazole-5-carboxylic acid hydrochloride (92534-70-8)

Guidance literature:

With hydrazine hydrate; nickel; In water; isopropyl alcohol; for 2h; Heating;

Reference yield:

1,5-dimethyl-1H-pyrazole (694-31-5) → 4-amino-1-methylpyrazole-5-carboxylic acid hydrochloride (92534-70-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / potassium permanganate

2: 96 percent / nitric acid (d 1.52), sulfuric acid monohydrate / 1.) 30-40 deg C, 1 h; 2.) 75-80 deg C, 2 h

3: 98 percent / 95percent hydrazine hydrate / Raney nickel / propan-2-ol; H₂O / 2 h / Heating

With potassium permanganate; sulfuric acid; nitric acid; hydrazine hydrate; nickel; In water; isopropyl alcohol;

Reference yield:

1-methyl-1H-pyrazole-5-carboxylic acid (16034-46-1) → 4-amino-1-methylpyrazole-5-carboxylic acid hydrochloride (92534-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / nitric acid (d 1.52), sulfuric acid monohydrate / 1.) 30-40 deg C, 1 h; 2.) 75-80 deg C, 2 h

2: 98 percent / 95percent hydrazine hydrate / Raney nickel / propan-2-ol; H₂O / 2 h / Heating

With sulfuric acid; nitric acid; hydrazine hydrate; nickel; In water; isopropyl alcohol;

upstream raw materials:

1-methyl-4-nitro-1H-pyrazole-5-carboxylic acid

1,5-dimethyl-1H-pyrazole

1-methyl-1H-pyrazole-5-carboxylic acid

Refernces