92534-69-5

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID is used as a building block for organic synthesis, playing a crucial role in the development of new pharmaceuticals. Its chemical structure allows for the creation of various drug candidates, contributing to the advancement of medicine and healthcare.
Used in Agrochemical Industry:
In the agrochemical sector, 2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID is utilized as an intermediate in the production of agrochemicals. Its properties make it suitable for the synthesis of compounds that can be used in pest control and crop protection, thereby supporting agricultural productivity.
Used in Dye Industry:
2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID is employed as a key component in the synthesis of dyes. Its chemical properties enable the production of a range of dyes with specific color characteristics, which are used in various applications such as textiles, plastics, and printing inks.
Used as an Antimicrobial Agent:
2-METHYL-4-NITRO-2H-PYRAZOLE-3-CARBOXYLIC ACID is known for its antimicrobial properties, making it a potential candidate for applications in the field of medicine and healthcare. Its ability to inhibit the growth of microorganisms can be leveraged in the development of antimicrobial products, contributing to infection control and prevention strategies.

Upstream product

• 3185-99-7 Methyl p-tolyl sulfone 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 309740-49-6 methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate 
• 694-31-5 1,5-dimethyl-1H-pyrazole 
• 75092-30-7 4-iodo-1-methyl-1H-pyrazole-5-carboxylic acid 
• 16034-46-1 1-methyl-1H-pyrazole-5-carboxylic acid 

Downstream Products

• 92534-73-1 4-amino-1-methyl-1H-pyrazole-5-carboxamide 
• 939979-32-5 5,7-dichloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine 
• 83824-38-8 1-methyl-1H-pyrazolo[4,3-d]pyrimidine-5,7-(4H,6H)-dione 
• 309740-49-6 methyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate 

Relevant academic research and scientific papers

DNA POLYMERASE IIIC INHIBITORS AND USE THEREOF

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections.

FGFR4 INHIBITORS

Methods, compounds, pharmaceutical compositions, and methods of preparing medicaments for treating hepatocellular carcinoma having an altered FGFR4 and/or FGF19 status.

FGFR4 INHIBITORS

We provide FGFR inhibitors, their salts, methods of manufacture, and methods of use.

Methylation of 4-nitro-3(5)-pyrazolecarboxylic acid

Reactions of 4-nitro-3(5)-pyrazolecarboxylic acid dipotassium salt with different methylating agents in various solvents have been investigated to improve the synthesis of isomeric 1-methyl-4-nitro-3- and -5-pyrazolecarboxylic acids.

PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE and INFLAMMATORY DISEASES

The present invention relates to compounds that are inhibitors of PDElA, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation, and particular

PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE and INFLAMMATORY DISEASES

The present invention relates to compounds that are inhibitors of PDElA, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation, and particular

Pyrazole Compound

The present invention provides a pyrazole compound represented by the formula (I): wherein ring A0 is a pyrazole ring optionally further having 1 or 2 substituents; Ra is a substituted carbamoyl group; and Rb is an optionally substituted acylamino group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of GSK-3β related pathology or disease, and a GSK-3β inhibitor including same.

Novel compounds useful for the treatment of degenerative and inflammatory diseases

The present invention relates to compounds that are inhibitors of PDE1A, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation.

ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2

We have developed a series of novel potent ortho-substituted azole derivatives active against kinases VEGFR-1 and VEGFR-2. Both specific and dual ATP-competitive inhibitors of VEGFR-2 were identified. Kinase activity and selectivity could be controlled by varying the arylamido substituents at the azole ring. The most specific molecule (17) displayed >10-fold selectivity for VEGFR-2 over VEGFR-1. Compound activities in enzymatic and cell-based assays were in the range of activities for reported clinical and development candidates (IC50 30 × 10-5 cm/min) is indicative of their potential for intestinal absorption upon oral administration.

PYRAZOLE COMPOUND

The present invention provides a pyrazole compound represented by the formula (I): wherein ring A0 is a pyrazole ring optionally further having 1 or 2 substituents; Ra is a substituted carbamoyl group; and Rb is an optionally substituted acylamino group, or a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of GSK-3β related pathology or disease, and a GSK-3β inhibitor including same.