Hydromadinone acetate

Base Information

• Chemical Name: Hydromadinone acetate
• CAS No.: 2477-73-8
• Molecular Formula: C23H31 Cl O4
• Molecular Weight: 406.95
• European Community (EC) Number: 607-437-1
• NSC Number: 33170
• UNII: X8WV0125VZ
• DSSTox Substance ID: DTXSID901226145
• Nikkaji Number: J66.972E
• Wikipedia: Hydromadinone_acetate
• Wikidata: Q27116093
• Mol file: 2477-73-8.mol

Synonyms:6-chloro-17-acetoxyprogesterone;hydromadinone acetate;hydromadinone acetate, (6alpha)-isomer;hydromadinone acetate, (6beta)-isomer

Chemical Property of Hydromadinone acetate

Chemical Property:

• Vapor Pressure: 6.95E-11mmHg at 25°C
• Melting Point: 192 °C
• Boiling Point: 519.3°Cat760mmHg
• Flash Point: 174°C
• PSA: 60.44000
• Density: 1.21g/cm³
• LogP: 4.62650
• Storage Temp.: Amber Vial, -20°C Freezer
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 406.1910872
• Heavy Atom Count: 28
• Complexity: 773

Purity/Quality:

99%, ^*data from raw suppliers

6α-Chloro-17-acetoxyProgesterone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1(CCC2C1(CCC3C2CC(C4=CC(=O)CCC34C)Cl)C)OC(=O)C
• Isomeric SMILES: CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C[C@@H](C4=CC(=O)CC[C@]34C)Cl)C)OC(=O)C
• Uses: Progesterone (P755900) impurity.

Technology Process of Hydromadinone acetate

There total 9 articles about Hydromadinone acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6β-Chlor-17α-hydroxyprogesteron-17-acetat (2477-73-8,2658-74-4,4994-50-7,4994-51-8,33125-90-5)

Guidance literature:

17α-Acetoxy-progesteron-3-yl-acetat, 1,3-Dichlor-5,5-dimethylhydantoin, Aceton, Wasser;

Reference yield:

→ 6α-Chlor-17α-hydroxyprogesteron-17-acetat (2477-73-8,2658-74-4,4994-50-7,4994-51-8,33125-90-5)

Guidance literature:

corresponding 6β-isomer, CHCl3 containing HCl (isomerisation);

Reference yield:

17α-acetoxy-6β-chloropregn-4-ene-3,20-dione (2658-74-4) → 17α-acetoxy-6α-chloropregn-4-ene-3,20-dione (2477-73-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01522a090

upstream raw materials:

17α-acetoxy-6β-chloropregn-4-ene-3,20-dione

17-acetoxy-3-ethoxy-pregna-3,5-dien-20-one

Downstream raw materials:

chlormadinone acetate

17-acetoxy-6α-chloro-pregna-1,4-diene-3,20-dione