Phosphonic acid, P-[[(1S)-1-[[4-[(2-hydroxyethyl)amino]-2-oxo-1(2H)-pyrimidinyl]methyl]-2 -(triphenylmethoxy)ethoxy]methyl]-, bis(1-methylethyl) ester

Base Information

Chemical Name:Phosphonic acid, P-[[(1S)-1-[[4-[(2-hydroxyethyl)amino]-2-oxo-1(2H)-pyrimidinyl]methyl]-2 -(triphenylmethoxy)ethoxy]methyl]-, bis(1-methylethyl) ester
CAS No.:925683-51-8
Molecular Formula:C₃₅H₄₄N₃O₇P
Molecular Weight:649.724
Hs Code.:

Phosphonic acid,
P-[[(1S)-1-[[4-[(2-hydroxyethyl)amino]-2-oxo-1(2H)-pyrimidinyl]methyl]-2
-(triphenylmethoxy)ethoxy]methyl]-, bis(1-methylethyl) ester

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Chemical Property of Phosphonic acid, P-[[(1S)-1-[[4-[(2-hydroxyethyl)amino]-2-oxo-1(2H)-pyrimidinyl]methyl]-2 -(triphenylmethoxy)ethoxy]methyl]-, bis(1-methylethyl) ester

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Technology Process of Phosphonic acid, P-[[(1S)-1-[[4-[(2-hydroxyethyl)amino]-2-oxo-1(2H)-pyrimidinyl]methyl]-2 -(triphenylmethoxy)ethoxy]methyl]-, bis(1-methylethyl) ester

There total 3 articles about Phosphonic acid, P-[[(1S)-1-[[4-[(2-hydroxyethyl)amino]-2-oxo-1(2H)-pyrimidinyl]methyl]-2 -(triphenylmethoxy)ethoxy]methyl]-, bis(1-methylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.3%

: 925683-41-6
[1-(4-methoxy-2-oxo-2H-pyrimidin-1-ylmethyl)-2-trityloxy-ethoxymethyl]-phosphonic acid diisopropyl ester

: 141-43-5
ethanolamine

: 925683-51-8
{1-[4-(2-hydroxy-ethylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-2-trityloxy-ethoxymethyl}-phosphonic acid diisopropyl ester

Guidance literature:: In 1,4-dioxane; Heating;
DOI:10.1135/cccc20052053

Reference yield:

: 1-[2-hydroxy-3-(trityloxy)propyl]-4-methoxypyrimidin-2(1H)-one

: 925683-51-8
{1-[4-(2-hydroxy-ethylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-2-trityloxy-ethoxymethyl}-phosphonic acid diisopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 50 °C

2: 77.3 percent / dioxane / Heating

With sodium hydride; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1135/cccc20052053

Reference yield:

: 129940-50-7
(S)-tritylglycidol

: 925683-51-8
{1-[4-(2-hydroxy-ethylamino)-2-oxo-2H-pyrimidin-1-ylmethyl]-2-trityloxy-ethoxymethyl}-phosphonic acid diisopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: cesium carbonate / dimethylformamide / 100 °C

2: NaH / tetrahydrofuran / 50 °C

3: 77.3 percent / dioxane / Heating

With sodium hydride; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1135/cccc20052053