Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(phenylmethoxy)carbonyl]amino]-1,3-propanediyl] ester

Base Information

Chemical Name:Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(phenylmethoxy)carbonyl]amino]-1,3-propanediyl] ester
CAS No.:925704-32-1
Molecular Formula:C27H29Cl6N3O7
Molecular Weight:720.261
Hs Code.:

Ethanimidic acid, 2,2,2-trichloro-,
1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[
[(phenylmethoxy)carbonyl]amino]-1,3-propanediyl] ester

Synonyms:

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Chemical Property of Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(phenylmethoxy)carbonyl]amino]-1,3-propanediyl] ester

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Technology Process of Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(phenylmethoxy)carbonyl]amino]-1,3-propanediyl] ester

There total 5 articles about Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-1-[4,5-dimethoxy-3-methyl-2-(2-propen-1-yloxy)phenyl]-2-[ [(phenylmethoxy)carbonyl]amino]-1,3-propanediyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 925704-12-7
benzyl (1R,2R)-1-(2-allyloxy-4,5-dimethoxy-3-methylphenyl)-1,3-dihydroxypropan-2-ylcarbamate

: 545-06-2
trichloroacetonitrile

: 925704-32-1
(1R,2R)-1-(2-allyloxy-4,5-dimethoxy-3-methylphenyl)-2-(benzyloxycarbonylamino)propane-1,3-diyl bis(2,2,2-trichloroacetimidate)

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/ol0627202

Reference yield:

: 925703-89-5
tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

: 925704-32-1
(1R,2R)-1-(2-allyloxy-4,5-dimethoxy-3-methylphenyl)-2-(benzyloxycarbonylamino)propane-1,3-diyl bis(2,2,2-trichloroacetimidate)

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃; NaI / acetone / 16 h / 20 °C

2.1: p-toluenesulfonic acid / methanol / 2 h / 0 °C

3.1: trifluoromethanesulfonic acid / CH₂Cl₂ / 0.5 h / 20 °C

3.2: 61 percent / NaHCO₃ / dioxane; H₂O / 20 h / 20 °C

4.1: 70 percent / DBU / CH₂Cl₂ / 1 h / 0 - 20 °C

With trifluorormethanesulfonic acid; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In methanol; dichloromethane; acetone;
DOI:10.1021/ol0627202

Reference yield:

: 925704-02-5
tert-butyl (1R,2R)-1-(2-allyloxy-4,5-dimethoxy-3-methylphenyl)-1,3-dihydroxypropan-2-ylcarbamate

: 925704-32-1
(1R,2R)-1-(2-allyloxy-4,5-dimethoxy-3-methylphenyl)-2-(benzyloxycarbonylamino)propane-1,3-diyl bis(2,2,2-trichloroacetimidate)

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoromethanesulfonic acid / CH₂Cl₂ / 0.5 h / 20 °C

1.2: 61 percent / NaHCO₃ / dioxane; H₂O / 20 h / 20 °C

2.1: 70 percent / DBU / CH₂Cl₂ / 1 h / 0 - 20 °C

With trifluorormethanesulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane;
DOI:10.1021/ol0627202