tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

Chemical Name:tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate
CAS No.:925703-89-5
Molecular Formula:C₂₀H₃₁NO₇
Molecular Weight:397.469
Hs Code.:

Synonyms:tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

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Chemical Property of tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

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Technology Process of tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

There total 1 articles about tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 95715-87-0
(R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine

: 50827-64-0
3,4-dimethyoxy-2-methylphenol

: 925703-89-5
tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

Guidance literature:: 3,4-dimethyoxy-2-methylphenol; With methylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

(R)-3-tert-butoxycarbonyl-4-formyl-2,2-dimethyloxazolidine; In dichloromethane; at 0 - 20 ℃; for 15h;
DOI:10.1021/ol0627202

Reference yield:

: 925703-89-5
tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

: 106-95-6
allyl bromide

: 4-[(2-allyloxy-4,5-dimethoxy-3-methyl-phenyl)-hydroxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; sodium iodide; In acetone; at 20 ℃; for 16h;
DOI:10.1021/ol0627202

Reference yield:

: 925703-89-5
tert-butyl (R)-4-((R)-hydroxy(2-hydroxy-4,5-dimethoxy-3-methylphenyl)methyl)-2,2-dimethyloxazolidine-3-carboxylate

: 925704-02-5
tert-butyl (1R,2R)-1-(2-allyloxy-4,5-dimethoxy-3-methylphenyl)-1,3-dihydroxypropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃; NaI / acetone / 16 h / 20 °C

2: p-toluenesulfonic acid / methanol / 2 h / 0 °C

With potassium carbonate; toluene-4-sulfonic acid; sodium iodide; In methanol; acetone;
DOI:10.1021/ol0627202