Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[5-(1,1-dimethyl ethyl)-2-(2-propen-1-yloxy)phenyl]-1,3-propanediyl] ester

Base Information

Chemical Name:Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[5-(1,1-dimethyl ethyl)-2-(2-propen-1-yloxy)phenyl]-1,3-propanediyl] ester
CAS No.:925704-34-3
Molecular Formula:C25H33Cl6N3O5
Molecular Weight:668.272
Hs Code.:

Ethanimidic acid, 2,2,2-trichloro-,
1,1'-[(1R,2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[5-(1,1-dimethyl
ethyl)-2-(2-propen-1-yloxy)phenyl]-1,3-propanediyl] ester

Synonyms:

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Chemical Property of Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[5-(1,1-dimethyl ethyl)-2-(2-propen-1-yloxy)phenyl]-1,3-propanediyl] ester

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Technology Process of Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[5-(1,1-dimethyl ethyl)-2-(2-propen-1-yloxy)phenyl]-1,3-propanediyl] ester

There total 5 articles about Ethanimidic acid, 2,2,2-trichloro-, 1,1'-[(1R,2R)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[5-(1,1-dimethyl ethyl)-2-(2-propen-1-yloxy)phenyl]-1,3-propanediyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 925704-04-7
tert-butyl (1R,2R)-1-(5-tert-butyl-2-(allyloxy)phenyl)-1,3-dihydroxypropan-2-ylcarbamate

: 545-06-2
trichloroacetonitrile

: 925704-34-3
(1R,2R)-1-(2-allyloxy-5-tert-butylphenyl)-2-(tert-butoxycarbonylamino)propane-1,3-diyl bis(2,2,2-trichloroacetimidate)

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1021/ol0627202

Reference yield:

: 4-[(2-allyloxy-5-tert-butyl-phenyl)-hydroxy-methyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 925704-34-3
(1R,2R)-1-(2-allyloxy-5-tert-butylphenyl)-2-(tert-butoxycarbonylamino)propane-1,3-diyl bis(2,2,2-trichloroacetimidate)

Guidance literature:: Multi-step reaction with 2 steps

1: p-toluenesulfonic acid / methanol / 2 h / 0 °C

2: 67 percent / DBU / CH₂Cl₂ / 1 h / 0 - 20 °C

With toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane;
DOI:10.1021/ol0627202

Reference yield:

: 98-54-4
para-tert-butylphenol

: 925704-34-3
(1R,2R)-1-(2-allyloxy-5-tert-butylphenyl)-2-(tert-butoxycarbonylamino)propane-1,3-diyl bis(2,2,2-trichloroacetimidate)

Guidance literature:: Multi-step reaction with 4 steps

1.1: methyl magnesium chloride / tetrahydrofuran / 0.17 h / 20 °C

1.2: 56 percent / CH₂Cl₂ / 15 h / 0 - 20 °C

2.1: K₂CO₃; NaI / acetone / 16 h / 20 °C

3.1: p-toluenesulfonic acid / methanol / 2 h / 0 °C

4.1: 67 percent / DBU / CH₂Cl₂ / 1 h / 0 - 20 °C

With methylmagnesium chloride; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; acetone;
DOI:10.1021/ol0627202