(4Z)-4-benzylidene-2-(4-methoxyphenyl)-1,3-oxazol-5(4H)-one

Base Information

Chemical Name:(4Z)-4-benzylidene-2-(4-methoxyphenyl)-1,3-oxazol-5(4H)-one
CAS No.:34108-13-9
Molecular Formula:C17H13NO3
Molecular Weight:279.295
Hs Code.:
NSC Number:149049
Nikkaji Number:J3.106.716B
ChEMBL ID:CHEMBL1996992

Synonyms:34108-13-9;(4Z)-4-benzylidene-2-(4-methoxyphenyl)-1,3-oxazol-5(4H)-one;4-Benzylidene-2-(4-methoxyphenyl)oxazol-5(4H)-one;NSC149049;CHEMBL1996992;STK277229;AKOS001019185;NSC-149049;SR-01000552573;SR-01000552573-1;2-(4-Methoxyphenyl)-4-[(Z)-benzylidene]-2-oxazoline-5-one

Suppliers and Price of (4Z)-4-benzylidene-2-(4-methoxyphenyl)-1,3-oxazol-5(4H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of (4Z)-4-benzylidene-2-(4-methoxyphenyl)-1,3-oxazol-5(4H)-one

Chemical Property:

Vapor Pressure:2.81E-07mmHg at 25°C
Boiling Point:420.5°Cat760mmHg
Flash Point:186.6°C
Density:1.18g/cm³
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:279.08954328
Heavy Atom Count:21
Complexity:441

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=NC(=CC3=CC=CC=C3)C(=O)O2
Isomeric SMILES:COC1=CC=C(C=C1)C2=N/C(=C\C3=CC=CC=C3)/C(=O)O2

Technology Process of (4Z)-4-benzylidene-2-(4-methoxyphenyl)-1,3-oxazol-5(4H)-one

There total 6 articles about (4Z)-4-benzylidene-2-(4-methoxyphenyl)-1,3-oxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: C₁₇H₁₃N₃O₄

: 34108-13-9
2-(p-Methoxyphenyl)-4-benzylidene-2-oxazolin-5-one

Guidance literature:: With 1,1,3,3-Tetramethyldisiloxane; copper(II) bis(trifluoromethanesulfonate); triphenylphosphine; In toluene; Reflux;
DOI:10.1021/acscatal.6b00165

Reference yield:

: 217446-35-0
4-benzyl-2-(4-methoxyphenyl)-5-oxo-4,5-dihydrooxazole

: 34108-13-9
2-(p-Methoxyphenyl)-4-benzylidene-2-oxazolin-5-one

Guidance literature:: With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; for 5h; Yield given; Heating;
DOI:10.1021/jo01294a046

Reference yield:

: 103678-74-6
N-(4-methoxybenzoyl)-phenylalanine

: 34108-13-9
2-(p-Methoxyphenyl)-4-benzylidene-2-oxazolin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: DCC / tetrahydrofuran / 1.5 h

2: 1,3-dibromo-5,5-dimethylhydantoin (Dibromantin), K₂CO₃ / Benzoyl peroxide / tetrahydrofuran / 5 h / Heating

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium carbonate; dicyclohexyl-carbodiimide; dibenzoyl peroxide; In tetrahydrofuran;
DOI:10.1021/jo01294a046