Technology Process of Octanamide,
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-, (2R)-
There total 1 articles about Octanamide,
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-, (2R)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide;
With
lithium chloride; lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 1.5h;
1-Iodohexane;
In
tetrahydrofuran; hexane;
at 20 ℃;
Further stages.;
DOI:10.1021/ol062834d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 87 percent / Li(NH2)BH3 / tetrahydrofuran; hexane / 2 h / 20 °C
2: 84 percent / (COCl)2; DMSO; triethylamine / CH2Cl2 / 0.33 h / -30 °C
With
oxalyl dichloride; lithium amidotrihydridoborate; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane;
2: Swern oxidation;
DOI:10.1021/ol062834d
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 87 percent / Li(NH2)BH3 / tetrahydrofuran; hexane / 2 h / 20 °C
2.1: 84 percent / (COCl)2; DMSO; triethylamine / CH2Cl2 / 0.33 h / -30 °C
3.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.17 h / -78 °C
3.2: 91 percent / tetrahydrofuran; hexane / 2 h / -78 - -20 °C
4.1: 90 percent / Dibal-H / hexane / 0.5 h / -78 °C
5.1: 86 percent / MnO2 / CH2Cl2 / 2 h
With
manganese(IV) oxide; oxalyl dichloride; lithium amidotrihydridoborate; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; dichloromethane;
2.1: Swern oxidation;
DOI:10.1021/ol062834d
