?-MAPI

Base Information

Chemical Name:?-MAPI
CAS No.:70857-49-7
Molecular Formula:C30H41N7O6
Molecular Weight:595.6898
Hs Code.:
Mol file:70857-49-7.mol

Synonyms:α-MAPI;(S)-2-(3-{(S)-1-[(S)-1-((S)-1-Formyl-2-phenyl-ethylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid;

Suppliers and Price of ?-MAPI

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of ?-MAPI

Chemical Property:

Melting Point:204 - 205 °C
Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：215.60000
Density:1.3g/cm³
LogP:3.43510
Storage Temp.:−20°C

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ?-MAPI

There total 12 articles about ?-MAPI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 212122-19-5
(S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid

: 70857-49-7
α-microbial alkaline proteinase inhibitor

Guidance literature:: With sodium periodate; water; In methanol; for 0.75h;
DOI:10.1039/a802380h

Reference yield:

: 16874-17-2
L-phenylalanine tert-butyl ester

: 70857-49-7
α-microbial alkaline proteinase inhibitor

Guidance literature:: Multi-step reaction with 7 steps

1.1: 85.9 percent / acetonitrile / 2.5 h / 20 °C

2.1: N-methylmorpholine / CH₂Cl₂

2.2: 70 percent / CH₂Cl₂ / 24 h / 20 °C

3.1: 99 percent / H₂ / Pd/C / acetic acid / 2.5 h / 20 °C

4.1: N-methylmorpholine / tetrahydrofuran / 0 °C

4.2: 90 percent / EDCI; HOBt / CH₂Cl₂ / 0 - 20 °C

5.1: 92 percent / H₂ / Pd/C / acetic acid / 4.5 h / 20 °C

6.1: 63 percent / PDC; 4 Angstroem molecular sieves; celite 545 / CH₂Cl₂ / 3.5 h / 20 °C

7.1: MeSO₃H; anisole / 0.67 h / 20 °C

With 4-methyl-morpholine; dipyridinium dichromate; methanesulfonic acid; 4 A molecular sieve; Celite; hydrogen; methoxybenzene; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid; acetonitrile;
DOI:10.1016/S0040-4020(01)00323-4

Reference yield:

: 189563-90-4
C₂₇H₃₇N₅O₈S

: 70857-49-7
α-microbial alkaline proteinase inhibitor

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-methylmorpholine / tetrahydrofuran / 0 °C

1.2: 90 percent / EDCI; HOBt / CH₂Cl₂ / 0 - 20 °C

2.1: 92 percent / H₂ / Pd/C / acetic acid / 4.5 h / 20 °C

3.1: 63 percent / PDC; 4 Angstroem molecular sieves; celite 545 / CH₂Cl₂ / 3.5 h / 20 °C

4.1: MeSO₃H; anisole / 0.67 h / 20 °C

With 4-methyl-morpholine; dipyridinium dichromate; methanesulfonic acid; 4 A molecular sieve; Celite; hydrogen; methoxybenzene; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1016/S0040-4020(01)00323-4