(S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid

Base Information

• Chemical Name: (S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid
• CAS No.: 212122-19-5
• Molecular Formula: C₃₁H₄₅N₇O₇
• Molecular Weight: 627.741
• Mol file: 212122-19-5.mol

Synonyms:(S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid

Chemical Property of (S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid

There total 1 articles about (S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1'-carbonyldiimidazole (530-62-1) + valine-tri-tert-butoxysilyl ester + arginine-(NG-NO2)-tri-tert-butoxysilyl ester + 4-phenyl-3-aminobutane-1,2-diol → (S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid (212122-19-5)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1039/a802380h

Reference yield: 84.0%

(S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid (212122-19-5) → α-microbial alkaline proteinase inhibitor (70857-49-7)

Guidance literature:

With sodium periodate; water; In methanol; for 0.75h;

DOI:10.1039/a802380h

Reference yield:

(S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid (212122-19-5) → Mer-N5075A

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / NaIO₄, H₂O / methanol / 0.75 h

2: 64 percent / NaBH₄ / methanol / 0.5 h

With sodium tetrahydroborate; sodium periodate; water; In methanol;

DOI:10.1039/a802380h

upstream raw materials:

1,1'-carbonyldiimidazole

Downstream raw materials:

α-microbial alkaline proteinase inhibitor