Psychosine

Base Information

Chemical Name:Psychosine
CAS No.:2238-90-6
Molecular Formula:C₂₄H₄₇NO₇
Molecular Weight:461.64
Hs Code.:
European Community (EC) Number:636-571-3
UNII:BG5A25U68L
Metabolomics Workbench ID:34359
Nikkaji Number:J1.822.469K,J39.570F
Wikidata:Q25106489
Wikipedia:Psychosine
Mol file:2238-90-6.mol

Synonyms:Galactoside, Sphingosine;Galactosylsphingosine;Psychosine;Sphingosine Galactoside

Suppliers and Price of Psychosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Psychosine
1mg
$ 602.00

TRC
Psychosine
5mg
$ 1075.00

Sigma-Aldrich
Psychosine from bovine brain lyophilized powder, ≥98% (TLC)
1mg
$ 78.60

Sigma-Aldrich
Psychosine from bovine brain lyophilized powder, ≥98% (TLC)
10mg
$ 409.00

Cayman Chemical
Galactosylsphingosine (d18:1) ≥95%
10mg
$ 275.00

Cayman Chemical
Galactosylsphingosine (d18:1) ≥95%
1mg
$ 50.00

Cayman Chemical
Galactosylsphingosine (d18:1) ≥95%
5mg
$ 188.00

Biosynth Carbosynth
b-D-Galactosylsphingosine - Synthetic
1 mg
$ 110.00

Biosynth Carbosynth
b-D-Galactosylsphingosine - Synthetic
2 mg
$ 190.00

Biosynth Carbosynth
b-D-Galactosylsphingosine - Synthetic
5 mg
$ 375.00

Total 14 raw suppliers

Chemical Property of Psychosine

Chemical Property:

Appearance/Colour:White powder
Vapor Pressure:1.77E-20mmHg at 25°C
Melting Point:190 °C (decomp)
Boiling Point:664.3ºC
PKA:11.74±0.45(Predicted)
Flash Point:355.6 ºC
PSA：145.63000
Density:1.14 g/cm³
LogP:2.44870
Storage Temp.:−20°C
XLogP3:3.7
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:18
Exact Mass:461.33525284
Heavy Atom Count:32
Complexity:479

Purity/Quality:

98%,99%, ^*data from raw suppliers

Psychosine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/21/22
Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCCCCCCCCCCCCC=CC(C(COC1C(C(C(C(O1)CO)O)O)O)N)O
Isomeric SMILES:CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)O)O)N)O
Description Galactosylsphingosine is a bioactive sphingolipid. It potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes, effects that can be reversed by the sphingosine-1-phosphate receptor agonist FTY720 phosphate . Galactosylsphingosine (0.1 and 1 μM) induces demyelination of mouse cerebellar slices. It inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes. Galactosylsphingosine (10 and 15 μM) inhibits gene transcription mediated by peroxisome proliferator-activated receptor α (PPARα) in reporter assays using C6 glial cells. Levels of galactosylsphingosine are increased in postmortem brain from patients with Krabbe disease, a lysosomal storage disorder characterized by a β-galactosylceramidase deficiency.[Matreya, LLC. Catalog No. 1305]
Uses Psychosine is a cationic lysosphingolipid that displays neuroprotective effects against quisqualate.

Technology Process of Psychosine

There total 12 articles about Psychosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 118711-45-8
(2S,3R,4E)-2-azido-1-(galactopyranosyloxy)octadec-4-en-3-ol

: 2238-90-6,52050-17-6,56453-02-2,95119-84-9,95975-32-9,106565-70-2
psychosine

Guidance literature:: With pyridine; hydrogen sulfide; In water; for 48.25h;

Reference yield: 21.0%

: 2021-84-3
α-galactosyl fluoride

: 123-78-4
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol

: 2238-90-6,52050-17-6,56453-02-2,95119-84-9,95975-32-9,106565-70-2
psychosine

Guidance literature:: α-galactosyl fluoride; (2S,3R,4E)-2-amino-4-octadecene-1,3-diol; With alpha cyclodextrin; In methanol; at 40 ℃; for 0.25h; pH=7.5; Sonication;

With endogalactosylceramidase from Rhodococcus equi E₃₄₁S mutant; In methanol; at 37 ℃; for 72h; Enzymatic reaction;
DOI:10.1016/j.carres.2016.09.013