1H-Pyrrole-2-carboxylic acid, 2-[(S)-cyclohexyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,5-dihydro -3-methyl-5-oxo-, ethyl ester, (2S)-

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxylic acid, 2-[(S)-cyclohexyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,5-dihydro -3-methyl-5-oxo-, ethyl ester, (2S)-
• CAS No.: 926629-66-5
• Molecular Formula: C21H37NO4Si
• Molecular Weight: 395.615
• Mol file: 926629-66-5.mol

Synonyms:

Chemical Property of 1H-Pyrrole-2-carboxylic acid, 2-[(S)-cyclohexyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,5-dihydro -3-methyl-5-oxo-, ethyl ester, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-2-carboxylic acid, 2-[(S)-cyclohexyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,5-dihydro -3-methyl-5-oxo-, ethyl ester, (2S)-

There total 1 articles about 1H-Pyrrole-2-carboxylic acid, 2-[(S)-cyclohexyl[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,5-dihydro -3-methyl-5-oxo-, ethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C25H41NO6Si (926629-65-4) + ethanol (64-17-5) → C21H37NO4Si (926629-66-5)

Guidance literature:

With titanium(IV) isopropylate; at 110 ℃; for 6h; microwave irradiation;

Reference yield: 47.0%

C21H37NO4Si (926629-66-5) + 2-chloroethyl trifluoromethanesulfonate (73323-80-5) → C23H40ClNO4Si (926629-67-6)

Guidance literature:

C₂₁H₃₇NO₄Si; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

With chloro-trimethyl-silane; In tetrahydrofuran; at -78 ℃; for 2h;

2-chloroethyl trifluoromethanesulfonate; With lithium diisopropyl amide; more than 3 stages;

Reference yield: 47.0%

C21H37NO4Si (926629-66-5) + 2-chloroethyl trifluoromethanesulfonate (73323-80-5) → 2-[(tert-butyl-dimethyl-silanyloxy)-cyclohexyl-methyl]-4-(2-chloro-ethyl)-3-methylene-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:

C₂₁H₃₇NO₄Si; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.5h;

With chloro-trimethyl-silane; In tetrahydrofuran; at -78 ℃; for 2h;

2-chloroethyl trifluoromethanesulfonate; With lithium diisopropyl amide; more than 3 stages;

upstream raw materials:

C₂₅H₄₁NO₆Si

ethanol

Downstream raw materials:

C₂₃H₄₀ClNO₄Si

Refernces

• 1、 -. "ANALOGS OF SALINOSPORAMIDE A". Page/Page column 49; 56; 8/8. . Retrieved 2010/11/26.