1-BOC-4-BROMO-1H-INDAZOLE

Base Information

• Chemical Name: 1-BOC-4-BROMO-1H-INDAZOLE
• CAS No.: 926922-37-4
• Molecular Formula: C12H13BrN2O2
• Molecular Weight: 297.151
• Hs Code.: 2933990090
• Mol file: 926922-37-4.mol

Synonyms:1-Boc-4-bromo-1H-indazole;tert-Butyl 4-bromo-1H-indazole-1-carboxylate;

Chemical Property of 1-BOC-4-BROMO-1H-INDAZOLE

Chemical Property:

• PSA: 44.12000
• LogP: 3.58200
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1-BOC-4-Bromo-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-BROMO-1H-INDAZOLE

There total 2 articles about 1-BOC-4-BROMO-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-bromoindazole (186407-74-9) → tert-butyl 4-bromo-1H-indazole-1-carboxylate (926922-37-4)

Guidance literature:

With dmap; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-bromoindazole (186407-74-9) → tert-butyl 4-bromo-1H-indazole-1-carboxylate (926922-37-4) + tert-butyl 4-bromo-2H-indazole-2-carboxylate

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 3h; Overall yield = 3.2 g;

Reference yield: 88.0%

tert-butyl 4-bromo-1H-indazole-1-carboxylate (926922-37-4) + 4-methoxycarbonylphenylboronic acid (99768-12-4) → methyl 4-(1H-indazol-4-yl)benzoate

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; ethanol; at 140 ℃; for 0.5h; Sealed tube; Microwave irradiation;

DOI:10.1002/bkcs.11698

upstream raw materials:

di-tert-butyl dicarbonate

4-bromoindazole

Refernces

• 1、 -. "CYANOPYRROLIDINE DERVIVATIVES AS INHIBITORS FOR DUBS". Page/Page column 43. . Retrieved 2017/07/14.
• 2、 -. "UNSATURATED HETEROCYCLIC DERIVATIVES". Page/Page column 42. . Retrieved 2008/06/13.