4-BROMO (1H)INDAZOLE

Base Information

• Chemical Name: 4-BROMO (1H)INDAZOLE
• CAS No.: 186407-74-9
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.034
• Hs Code.: 2933990090
• Mol file: 186407-74-9.mol

Synonyms:4-Bromo-1H-indazole;

Chemical Property of 4-BROMO (1H)INDAZOLE

Chemical Property:

• Appearance/Colour: brown powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 165-167 °C
• Refractive Index: 1.728
• Boiling Point: 333.821 °C at 760 mmHg
• PKA: 12.78±0.40(Predicted)
• Flash Point: 155.69 °C
• PSA: 28.68000
• Density: 1.771 g/cm³
• LogP: 2.32540
• Storage Temp.: 2-8°C
• Solubility.: soluble in Ethanol

Purity/Quality:

99% ^*data from raw suppliers

4-Bromoindazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25-36/37/38
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO (1H)INDAZOLE

There total 24 articles about 4-BROMO (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-bromo-2-methylaniline (55289-36-6) → 4-bromoindazole (186407-74-9)

Guidance literature:

3-bromo-2-methylaniline; With acetic anhydride; In chloroform; at 20 ℃; for 1h;

With potassium acetate; isopentyl nitrite; for 18h; Heating / reflux;

With hydrogenchloride; at 50 ℃; for 2h; Heating / reflux;

Reference yield: 94.0%

1-(4-bromo-1H-indazol-1-yl)ethanone (885698-70-4) → 4-bromoindazole (186407-74-9)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 7h;

Reference yield: 88.0%

2-acetyl-4-bromo-2H-indazole (870526-64-0) → 4-bromoindazole (186407-74-9)

Guidance literature:

With hydrogenchloride; water; at 50 - 60 ℃; for 0.5h;

upstream raw materials:

2-bromo-6-fluorobenzaldehyde hydrazone

2-bromo-6-fluorobenzaldehyde benzylhydrazone

2-bromo-6-fluorobenzaldehyde

N-[(2-bromo-6-fluorophenyl)methylidene]hydroxylamine

Downstream raw materials:

2-benzyl-4-bromo-2H-indazole

1-benzyl-4-bromoindazole

4-bromo-1-{3-fluoro-4-[(phenylmethyl)oxy]phenyl}-1H-indazole

4-bromo-2-methylindazole

Refernces

• 1、 Folkes, Adrian J.,Ahmadi, Khatereh,Alderton, Wendy K.,Alix, Sonia,Baker, Stewart J.,Box, Gary,Chuckowree, Irina S.,Clarke, Paul A.,Depledge, Paul,Eccles, Suzanne A.,Friedman, Lori S.,Hayes, Angela,Hancox, Timothy C.,Kugendradas, Arumugam,Lensun, Letitia,Moore, Pauline,Olivero, Alan G.,Pang, Jodie,Patel, Sonal,Pergl-Wilson, Giles H.,Raynaud, Florence I.,Robson, Anthony,Saghir, Nahid,Salphati, Laurent,Sohal, Sukhjit,Ultsch, Mark H.,Valenti, Melanie,Wallweber, Heidi J. A.,Nan, Chi Wan,Wiesmann, Christian,Workman, Paul,Zhyvoloup, Alexander,Zvelebil, Marketa J.,Shuttleworth, Stephen J.. "The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer". . p. 5522 - 5532. Retrieved 2008.
• 2、 -. "PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH ZINC BINDING MOIETY". . . Retrieved 2016/10/07.