1H-Pyrrole-3-propanoic acid, 5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4-methyl-1H-pyrrol -2-yl]methyl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester

Base Information

Chemical Name:1H-Pyrrole-3-propanoic acid, 5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4-methyl-1H-pyrrol -2-yl]methyl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester
CAS No.:92735-25-6
Molecular Formula:C30H37ClN2O6
Molecular Weight:557.087
Hs Code.:

1H-Pyrrole-3-propanoic acid,
5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4-methyl-1H-pyrrol
-2-yl]methyl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester

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Chemical Property of 1H-Pyrrole-3-propanoic acid, 5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4-methyl-1H-pyrrol -2-yl]methyl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester

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Technology Process of 1H-Pyrrole-3-propanoic acid, 5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4-methyl-1H-pyrrol -2-yl]methyl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester

There total 5 articles about 1H-Pyrrole-3-propanoic acid, 5-[[3-(2-chloroethyl)-5-[(1,1-dimethylethoxy)carbonyl]-4-methyl-1H-pyrrol -2-yl]methyl]-4-methyl-2-[(phenylmethoxy)carbonyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 92735-21-2
t-butyl 5-acetoxymethyl-4-(2'-chloroethyl)-3-methylpyrrole-2-carboxylate

: 51671-83-1
benzyl 3-(2'-methoxycarbonylethyl)-4-methylpyrrole-2-carboxylate

: 92735-25-6
benzyl 5'-t-butoxycarbonyl-3'-(2-chloroethyl)-4-(2-methoxycarbonylethyl)-3,4'-dimethylpyrromethane-5-carboxylate

Guidance literature:: Ni-montmorillonite; In dichloromethane; for 1h;
DOI:10.1002/jlcr.2580340309

Reference yield:

: 33317-06-5
benzyl 3-<2-(methoxycarbonyl)ethyl>-4,5-methylpyrrole-2-carboxylate

: 92735-25-6
benzyl 5'-t-butoxycarbonyl-3'-(2-chloroethyl)-4-(2-methoxycarbonylethyl)-3,4'-dimethylpyrromethane-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1) sulfuryl chloride; 2) sodium acetate / 1) CCl₄, 3h, room temperature; 2) dioxan/water, reflux, 2h, room temperature

2: 80 percent / sodium bicarbonate, iodine, potassium iodide / methanol; H₂O / 60 °C

3: 90 percent / zinc dust, acetic acid / 3 h / Heating

4: 77 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 °C

With sulfuryl dichloride; iodine; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; potassium iodide; zinc; In methanol; water; acetic acid;
DOI:10.1016/S0040-4020(01)91126-3

Reference yield:

: 92735-20-1
t-butyl 4-(2'-chloroethyl)-3,5-dimethylpyrrole-2-carboxylate

: 92735-25-6
benzyl 5'-t-butoxycarbonyl-3'-(2-chloroethyl)-4-(2-methoxycarbonylethyl)-3,4'-dimethylpyrromethane-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / lead tetra-acetate / acetic acid

2: 77 percent / p-toluene sulfonic acid hydrate / acetic acid / 4 h / 45 °C

With lead(IV) acetate; toluene-4-sulfonic acid; In acetic acid;
DOI:10.1016/S0040-4020(01)91126-3