33317-06-5

Upstream product

• 67-56-1 methanol 
• 111017-85-7 3-(2-benzyloxycarbonyl-ethyl)-4,5-dimethyl-pyrrole-2-carboxylic acid benzyl ester 
• 99986-60-4 3-<2-(methoxycarbonyl)ethyl>-4,5-dimethylpyrrole-2-carboxaldehyde 
• 815-57-6 3-Methyl-2,4-pentanedione 
• 40515-74-0 3-(2-ethoxycarbonyl-ethyl)-5-methyl-pyrrole-2,4-dicarboxylic acid-2-ethyl ester 
• 100-51-6 benzyl alcohol 
• 1415799-34-6 C₁₃H₂₀O₆ 
• 50622-87-2 ethyl 2-ethoxycarbonyl-4-benzyloxycarbonyl-5-methylpyrrole-3-propionate 
• 101780-55-6 3-(2-ethoxycarbonyl-4-diethylaminomethyl-5-methyl-pyrrol-3-yl)-propionic acid ethyl ester 
• 17266-77-2 ethyl 3-[2-(ethoxycarbonyl)ethyl]-4,5-dimethyl-1H-pyrrole-2-carboxylate 
• 101767-10-6 3-<2-(methoxycarbonyl)ethyl>-4,5-dimethylpyrrole-2-carboxylic acid 
• 80480-42-8 methyl 4,6-dioxoheptanoate, keto-tautomer 
• 74839-00-2 methyl 5-methyl-4,6-dioxoheptanoate 
• 51118-40-2 dibenzyl 2-(hydroxyimino)malonate 

Downstream Products

• 51671-81-9 2-benzoyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methyl-5-(acetoxymethyl)pyrrole 
• 92735-18-7 5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-methylpyrrole-2-carboxylic acid 
• 101767-11-7 benzyl 3,5-di-(2-chloroethyl)-6-(2-methoxycarbonylethyl)-1,1',2,4-tetramethyltripyrrene-a-6'-carboxylate hydrobromide 
• 33317-09-8 benzyl 5'-t-butoxycarbonyl-3'-ethyl-4-(2-methoxycarbonylethyl)-3,4'-dimethylpyrromethane-5-carboxylate 
• 10035-62-8 α-biliverdin-IX dimethyl ester 
• 92735-28-9 benzyl 5'-t-butoxycarbonyl-4'-ethyl-4-(2-methoxycarbonylethyl)-3,3'-dimethylpyrromethane-5-carboxylate 
• 92735-19-8 benzyl 5-iodo-3-(2-methoxycarbonylethyl)-4-methylpyrrole-2-carboxylate 
• 92770-90-6 benzyl 5'-t-butoxycarbonyl-4'-(2-chloroethyl)-4-(2-methoxycarbonylethyl)-3,3'-dimethylpyrromethane-5-carboxylate 
• 92735-25-6 benzyl 5'-t-butoxycarbonyl-3'-(2-chloroethyl)-4-(2-methoxycarbonylethyl)-3,4'-dimethylpyrromethane-5-carboxylate 
• 160114-49-8 dibenzyl 4,4'-diethyl-3,3'-dimethyl-2,2'-pyrromethane-5,5'-dicarboxylate 
• 51671-83-1 benzyl 3-(2'-methoxycarbonylethyl)-4-methylpyrrole-2-carboxylate 
• 771440-85-8 {[5-tert-Butoxycarbonyl-4-(2-methoxycarbonyl-ethyl)-3-methyl-1H-pyrrol-2-yl]-cyano-methyl}-triphenyl-phosphonium 
• 101587-97-7 3-(2-carbamoyl-ethyl)-4,5-dimethyl-pyrrole-2-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Investigations regarding the utility of prodigiosenes to treat leukemia

Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed promising activity against leukemia cell lines during in v

Normal and abnormal heme biosynthesis. 2.1 Synthesis and metabolism of type-III pentacarboxylic porphyrinogens: Further experimental evidence for the enzymic clockwise decarboxylation of uroporphyrinogen-III

Uroporphyrinogen decarboxylase catalyses the sequential decarboxylation of uroporphyrinogen-III (1) to give coproporphyrinogen-III (2), a precursor to the hemes and chlorophylls. This involves the decarboxylation of four nonequivalent acetate side chains to produce methyl units and in principle could take place by 24 different pathways involving up to 14 intermediary porphyrinogens. In the past, seemingly contradictory data have been presented that either support an ordered 'clockwise' decarboxylation pathway or a random decarboxylation process. Four pentacarboxylate porphyrinogens might be involved immediately before the formation of 2, and these compounds have been synthesized as the corresponding porphyrin pentamethyl esters via tripyrrene and a,c-biladiene intermediates. Hydrolysis of the methyl esters and reduction with 3% sodium amalgam gave the required porphyrinogens, and these were incubated with crude enzyme preparations derived from chicken red cell hemolysates. One of these pentacarboxylate porphyrinogens. (5dab) consistently proved to be a much better substrate than the other three, providing new support for the 'clockwise' pathway for coproporphyrinogen-III formation.

Haem d1: Stereoselective synthesis of the reduced form of its parent macrocycle using the original coupling strategy

A substituted isobacteriochlorin, which corresponds structurally to the reduced metal-free macrocycle of haem d1, has been synthesised by a stereoselective route in which the final step is a photochemical 18π-electron antarafacial cyclisation of an open-chain precursor.

Synthetic and Biosynthetic Studies of Porphyrins. Part 8. Synthese of Hepta-, Hexa-, and penta-carboxylic Porphyrins Related to Urophorphin-I

The title porphyrins of interest as abnormal metabolits in porphyrins biosynthesis, have been synthesized by the Fischer, and b-oxobilane routes, and compared with the naturally derived materials.Enzymic experiments have shown that the conversion of uropo