L-Valine, N-[(2S)-2-[[(2R,3R)-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino] ethyl]-4-thiazolyl]carbonyl]amino]-2-methyl-1-oxohexyl]oxy]-1-oxopropyl]- N-methyl-L-phenylalanyl-N-methyl-, 1,1-dimethylethyl ester

Base Information

Chemical Name:L-Valine, N-[(2S)-2-[[(2R,3R)-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino] ethyl]-4-thiazolyl]carbonyl]amino]-2-methyl-1-oxohexyl]oxy]-1-oxopropyl]- N-methyl-L-phenylalanyl-N-methyl-, 1,1-dimethylethyl ester
CAS No.:927438-79-7
Molecular Formula:C41H63N5O9S
Molecular Weight:802.045
Hs Code.:

L-Valine,
N-[(2S)-2-[[(2R,3R)-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]
ethyl]-4-thiazolyl]carbonyl]amino]-2-methyl-1-oxohexyl]oxy]-1-oxopropyl]-
N-methyl-L-phenylalanyl-N-methyl-, 1,1-dimethylethyl ester

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Chemical Property of L-Valine, N-[(2S)-2-[[(2R,3R)-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino] ethyl]-4-thiazolyl]carbonyl]amino]-2-methyl-1-oxohexyl]oxy]-1-oxopropyl]- N-methyl-L-phenylalanyl-N-methyl-, 1,1-dimethylethyl ester

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Technology Process of L-Valine, N-[(2S)-2-[[(2R,3R)-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino] ethyl]-4-thiazolyl]carbonyl]amino]-2-methyl-1-oxohexyl]oxy]-1-oxopropyl]- N-methyl-L-phenylalanyl-N-methyl-, 1,1-dimethylethyl ester

There total 19 articles about L-Valine, N-[(2S)-2-[[(2R,3R)-3-[[[2-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino] ethyl]-4-thiazolyl]carbonyl]amino]-2-methyl-1-oxohexyl]oxy]-1-oxopropyl]- N-methyl-L-phenylalanyl-N-methyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 927438-80-0
3-tert-butoxycarbonylamino-2-methyl-hexanoic acid

: 927438-79-7
3-{[2-(1-tert-butoxycarbonylamino-ethyl)-thiazole-4-carbonyl]-amino}-2-methyl-hexanoic acid 1-({1-[(1-tert-butoxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-phenyl-ethyl}-methyl-carbamoyl)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / DCC; DMAP / CH₂Cl₂ / 16 h

2: 88 percent / TFA / CH₂Cl₂

3: 67 percent / DCC; hydroxybenzotriazole / CH₂Cl₂ / 16 h

4: 87 percent / H₂ / Pd-C

5: 55 percent / BOP; Et₃N / CH₂Cl₂

With dmap; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/j.tetlet.2006.11.117

Reference yield:

: 927438-82-2
benzyl (2R,3R)-3-amino-2-methylhexanoyl-L-lactic acid

: 927438-79-7
3-{[2-(1-tert-butoxycarbonylamino-ethyl)-thiazole-4-carbonyl]-amino}-2-methyl-hexanoic acid 1-({1-[(1-tert-butoxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-phenyl-ethyl}-methyl-carbamoyl)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / DCC; hydroxybenzotriazole / CH₂Cl₂ / 16 h

2: 87 percent / H₂ / Pd-C

3: 55 percent / BOP; Et₃N / CH₂Cl₂

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/j.tetlet.2006.11.117

Reference yield:

: 927438-77-5
benzyl (2R,3R)-3-(Boc-amino)-2-methylhexanoyl-L-lactic acid

: 927438-79-7
3-{[2-(1-tert-butoxycarbonylamino-ethyl)-thiazole-4-carbonyl]-amino}-2-methyl-hexanoic acid 1-({1-[(1-tert-butoxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-phenyl-ethyl}-methyl-carbamoyl)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / TFA / CH₂Cl₂

2: 67 percent / DCC; hydroxybenzotriazole / CH₂Cl₂ / 16 h

3: 87 percent / H₂ / Pd-C

4: 55 percent / BOP; Et₃N / CH₂Cl₂

With hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane;
DOI:10.1016/j.tetlet.2006.11.117