Technology Process of 2,4-Pentadienoic acid,
5-(4-methoxyphenyl)-4-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester,
(E,E)-
There total 4 articles about 2,4-Pentadienoic acid,
5-(4-methoxyphenyl)-4-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester,
(E,E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: p-toluene sulfonic acid / benzene / 15 h / 60 °C
2: p-toluene sulfonic acid / 0 degC, 0.2 h, then 20 degC, 6 h
3: 1) lithium diisopropylamide, 2) HMPT / 1) -78 degC, 0.1 h, THF, 2) -78 degC, 0.2 h, then -78 degC to 20 degC, 2 h, THF
With
N,N,N,N,N,N-hexamethylphosphoric triamide; toluene-4-sulfonic acid; lithium diisopropyl amide;
In
benzene;
DOI:10.1016/S0040-4039(01)81316-2
- Guidance literature:
-
Multi-step reaction with 2 steps
1: p-toluene sulfonic acid / 0 degC, 0.2 h, then 20 degC, 6 h
2: 1) lithium diisopropylamide, 2) HMPT / 1) -78 degC, 0.1 h, THF, 2) -78 degC, 0.2 h, then -78 degC to 20 degC, 2 h, THF
With
N,N,N,N,N,N-hexamethylphosphoric triamide; toluene-4-sulfonic acid; lithium diisopropyl amide;
DOI:10.1016/S0040-4039(01)81316-2
- Guidance literature:
-
Multi-step reaction with 2 steps
1: p-toluene sulfonic acid / 0 degC, 0.2 h, then 20 degC, 6 h
2: 1) lithium diisopropylamide, 2) HMPT / 1) -78 degC, 0.1 h, THF, 2) -78 degC, 0.2 h, then -78 degC to 20 degC, 2 h, THF
With
N,N,N,N,N,N-hexamethylphosphoric triamide; toluene-4-sulfonic acid; lithium diisopropyl amide;
DOI:10.1016/S0040-4039(01)81316-2
