L-Leucine, N-[N-[N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-L-leuc yl]-L-leucyl]-L-leucyl]-, phenylmethyl ester

Base Information

• Chemical Name: L-Leucine, N-[N-[N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-L-leuc yl]-L-leucyl]-L-leucyl]-, phenylmethyl ester
• CAS No.: 92782-19-9
• Molecular Formula: C48H82N6O9
• Molecular Weight: 887.214
• Mol file: 92782-19-9.mol

Synonyms:

Chemical Property of L-Leucine, N-[N-[N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-L-leuc yl]-L-leucyl]-L-leucyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Leucine, N-[N-[N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-L-leuc yl]-L-leucyl]-L-leucyl]-, phenylmethyl ester

There total 3 articles about L-Leucine, N-[N-[N-[N-[N-[N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl]-L-leucyl]-L-leuc yl]-L-leucyl]-L-leucyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Leu3-OBzl (32945-67-8) → Boc-Leu6-OBzl (92782-19-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 3 M HCl / ethyl acetate

2: NMM

3: DCC, HOBt / CH₂Cl₂

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;

DOI:10.1246/bcsj.62.1976

Reference yield:

H-Leu3-OBzl*HCl (95675-61-9) → Boc-Leu6-OBzl (92782-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NMM

2: DCC, HOBt / CH₂Cl₂

With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1246/bcsj.62.1976

Reference yield:

H-Leu3-OBzl (75666-40-9) + Boc-Leu3-OH (18868-20-7) → Boc-Leu6-OBzl (92782-19-9)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1246/bcsj.62.1976

upstream raw materials:

H-Leu₃-OBzl

Boc-Leu₃-OH

Boc-Leu₃-OBzl

H-Leu₃-OBzl*HCl

Downstream raw materials:

H-Leu₆-OBzl