Benzenebutanoic acid, a-cyano-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Benzenebutanoic acid, a-cyano-, 1,1-dimethylethyl ester
• CAS No.: 927895-16-7
• Molecular Formula: C15H19NO2
• Molecular Weight: 245.321
• Mol file: 927895-16-7.mol

Synonyms:

Chemical Property of Benzenebutanoic acid, a-cyano-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenebutanoic acid, a-cyano-, 1,1-dimethylethyl ester

There total 2 articles about Benzenebutanoic acid, a-cyano-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-phenylbutyronitrile (2046-18-6) → 2-cyano-4-phenylbutyric acid tert-butyl ester (927895-16-7)

Guidance literature:

4-phenylbutyronitrile; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 1.16667h;

di-tert-butyl dicarbonate; In tetrahydrofuran; hexane; at -78 ℃; for 2.16667h;

DOI:10.1021/ja068119g

Reference yield:

cyanoacetic acid tert-butyl ester (1116-98-9) + 1-phenyl-2-bromoethane (103-63-9) → 2-cyano-4-phenylbutyric acid tert-butyl ester (927895-16-7)

Guidance literature:

cyanoacetic acid tert-butyl ester; With potassium carbonate; In dimethyl sulfoxide; for 0.5h;

1-phenyl-2-bromoethane; In dimethyl sulfoxide; at 20 ℃; for 12h;

DOI:10.1002/anie.202000138

Reference yield: 89.0%

2-cyano-4-phenylbutyric acid tert-butyl ester (927895-16-7) + cyclohexenone (930-68-7) → 2-cyano-2-(3-oxo-cyclohexyl)-4-phenyl-butyric acid tert-butyl ester

Guidance literature:

With caesium carbonate; (S)-1,1'-binaphthyl derivative; In toluene; at 0 ℃; for 2h;

DOI:10.1021/ja068119g

upstream raw materials:

di-tert-butyl dicarbonate

4-phenylbutyronitrile

cyanoacetic acid tert-butyl ester

1-phenyl-2-bromoethane