3-(2-fluoro-4-(trifluoroMethyl)phenyl)-1H-pyrrole-2,5-dione

Base Information

• Chemical Name: 3-(2-fluoro-4-(trifluoroMethyl)phenyl)-1H-pyrrole-2,5-dione
• CAS No.: 927896-24-0
• Molecular Formula: C11H5F4NO2
• Molecular Weight: 259.16
• Mol file: 927896-24-0.mol

Synonyms:3-[2-fluoro-4-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione,3-[2-fluoro-4-(trifluoromethyl)phenyl];

Chemical Property of 3-(2-fluoro-4-(trifluoroMethyl)phenyl)-1H-pyrrole-2,5-dione

Chemical Property:

• PSA: 49.66000
• LogP: 2.16020
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-(2-Fluoro-4-(trifluoromethyl)phenyl)-1H-pyrrole-2,5-dione 95+% ^*data from reagent suppliers

Safty Information:

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(2-fluoro-4-(trifluoroMethyl)phenyl)-1H-pyrrole-2,5-dione

There total 1 articles about 3-(2-fluoro-4-(trifluoroMethyl)phenyl)-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.6%

maleiimide (541-59-3,25721-74-8) + 2-fluoro-4-(trifluoromethyl)aniline (69409-98-9) → 3-[2-fluoro-4-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione (927896-24-0)

Guidance literature:

With tert.-butylnitrite; copper dichloride; In acetonitrile; at 0 - 20 ℃;

Reference yield:

3-[2-fluoro-4-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione (927896-24-0) → 1(1R,5S/1S,5R)-[2-fluoro-4-(trifluoromethyl)pheny|]-3-azabicyclo-[3.1.0]hexane-2,4-dione (863679-52-1)

Guidance literature:

trimethylsulfoxonium iodide; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h;

3-[2-fluoro-4-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione; In dimethyl sulfoxide; at 20 - 25 ℃; for 2.66667h;

Reference yield:

3-[2-fluoro-4-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione (927896-24-0) → 1-(1R,5S/1S,5R)-[2-fluoro-4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hexane-2,4-dione

Guidance literature:

trimethylsulfoxonium iodide; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 1h;

3-[2-fluoro-4-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione; In dimethyl sulfoxide; at 20 - 25 ℃; for 2.5h;

With hydrogenchloride; In tert-butyl methyl ether; water; dimethyl sulfoxide; at 20 ℃; Product distribution / selectivity;

upstream raw materials:

maleiimide

2-fluoro-4-(trifluoromethyl)aniline

Downstream raw materials:

1(1R,5S/1S,5R)-[2-fluoro-4-(trifluoromethyl)pheny|]-3-azabicyclo-[3.1.0]hexane-2,4-dione

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