69409-98-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-4-(trifluoromethyl)aniline is used as a chemical intermediate for the synthesis of pharmaceutical compounds, leveraging its reactivity in chemical reactions such as nitration, acylation, and Friedel-Crafts reactions to produce a range of medicinally relevant molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Fluoro-4-(trifluoromethyl)aniline serves as a key component in the creation of pesticides and other agrochemical products, contributing to the development of effective solutions for crop protection and enhancement of agricultural yields.
Caution:
Given its known toxicity upon ingestion or inhalation, 2-Fluoro-4-(trifluoromethyl)aniline necessitates careful handling in laboratory and industrial environments to ensure safety and prevent health hazards.

InChI:InChI=1/C7H5F4N/c8-5-3-4(7(9,10)11)1-2-6(5)12/h1-3H,12H2

Upstream product

• 67-56-1 methanol 
• 2339-84-6 2-fluoro-4-(trifluoromethyl)-acetanilide 
• 51632-16-7 3-phenoxybenzyl bromide 
• 446-34-4 2-fluoro-4-methyl-1-nitrobenzene 
• 115029-24-8 2-fluoro-4-(trifluoromethyl)benzoic acid 
• 34913-29-6 4,4′-bis(trifluoromethyl)azobenzene 
• 348-54-9 2-Fluoroaniline 
• 88288-14-6 2-fluoro-4-(trifluoromethyl)acetanilide 
• 32137-19-2 1,2-difluoro-4-(trifluoromethyl)benzene 
• 349-97-3 4-(trifluromethyl)acetanilide 
• 455-14-1 4-trifluoromethylphenylamine 

Downstream Products

• 76338-70-0 2-(2-chloro-4-trifluoromethylphenylamino)-3-methylbutyronitrile 
• 927896-24-0 3-[2-fluoro-4-(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione 
• 1193487-71-6 6-fluoro-7-(2-fluoro-4-trifluoromethyl-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid 
• 1193487-93-2 7-(2-Fluoro-4-trifluoromethyl-phenylamino)-5-oxo-1,2,3,5-tetrahydro-indolizine-8-carboxylic acid ethyl ester 
• 401567-22-4 6-(trifluoromethyl)benzo[d]thiazole-2(3H)-thione 
• 1226805-38-4 1-chloro-3-fluoro-2-nitro-5-(trifluoromethyl)benzene 
• 1226805-39-5 1-(3-chloro-2-nitro-5-(trifluoromethyl)phenyl)-4-methyl-1H-imidazole 
• 1226805-40-8 2-chloro-6-(4-methyl-1H-imidazol-1-yl)-4-(trifluoromethyl)aniline 
• 1257138-88-7 N-(2-chloro-6-(4-methyl-1H-imidazol-1-yl)-4-(trifluoromethyl)phenyl)acetamide 
• 1260487-56-6 1-(2-fluoro-4-trifluoromethylphenyl)-3-(3-cyano-5-fluorophenyl)urea 
• 1000815-86-0 5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile 
• 1472654-48-0 5-amino-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylsulfinyl)-1H-pyrazole-3-carbonitrile 
• 1472654-49-1 5-bromo-1-(2-chloro-6-fluoro-4-(trifluoromethyl)phenyl)-4-(trifluoromethylsulfinyl)-1H-pyrazole-3-carbonitrile 
• 1374297-07-0 2-((2-chloro-6-fluorophenyl)amino)-N-(2-fluoro-4-(trifluoromethyl)phenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 

Relevant academic research and scientific papers

Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination

A detailed mechanism study on the anion ligand promoted selective C-H bond fluorination is reported. The role of the anion ligand has been clarified by experimental evidence and DFT calculations. Moreover, the nitrate promoted C-F bond reductive elimination enabled a selective C-H bond fluorination of various symmetric and asymmetric azobenzenes to access diverse o-fluoroanilines.

PROCESSES FOR THE PREPARATION OF 1-ARYL-5-ALKYL PYRAZOLE COMPOUNDS

Provided are improved processes for the preparation of 1-aryl pyrazole compounds of formula (I) and (IB): which are substituted at the 5-position of the pyrazole ring with a carbon-linked functional group. The process described are efficient and scalable

Process for producing 4-amino-3-fluorobenzotrifluoride

Disclosed is a process for producing 4-amino-3-fluorobenzotrifluoride which comprises reacting 3,4-difluorobenzotrifluoride with anhydrous ammonia (liquid ammonia or gaseous ammonia) under pressure.

Process for producing 2-fluoro-4-(trifluoromethyl) acetanilide

Disclosed is a process for producing 2-fluoro-4-(trifluoromethyl) acetanilide which comprises reacting 3,4-difluorobenzotrifluoride with acetamide in the presence of a base in an aprotic polar solvent or in a mixture of an aprotic polar solvent and an aprotic non-polar solvent.

Electrophilic fluorination of aromatic compounds

A process for the electrophilic ring fluorination of aromatic compounds which comprises reacting a fluorinating agent from the group consisting of CF3 OF and CF2 (OF)2 with an aromatic compound of the formula STR1 where X is selected from the group consisting of STR2 and STR3 and Y is selected from the group consisting of --H, --CF3, --CN, --NO2, --Cl, and CH3.

Fluorination of Aromatic Derivatives with Fluoroxytrifluoromethane and Bis(fluoroxy)difluoromethane

Fluoroxytrifluoromethane (CF3OF) and bis(fluoroxy)difluoromethane CF2(OF)2 are formed by the reaction of F2 with CO and CO2, respectively, over a CsF catalyst in a continouous-stream process.Both reagents react with aromatic substrates by an electrophilic substitution mechanism to yield fluoro-substituted derivatives.Fluorobenzene is produced in good yield from benzene, and aniline derivatives afford monofluorination products.Acetanilide (1), N-phenylmethanesulfonamide (2), α,α,α-trifluoroacetanilide (3), and 1,1,1-trifluoro(N-phenyl)methanesulfonamide (4) react with either reagent to yield mixtures of o- and p-fluoro-substituted derivatives.Solvent effects and competitive rate experiments demonstrate a preference for ortho substitution, especially in aprotic, nonpolar solvents.With particular substrates, these fluorinating agents are of practical synthetic utility, e.g., 2-fluoro-4-(trifluoromethyl)aniline is produced in high yield by fluorinating the intermediate 4-(trifluoromethyl)acetanilide (6) with CF3OF.Activated substrates such as toluene, xylenes, anisole, and cresols give mixtures of products which reduce the synthetic utility of these reagents.Nitrobenzene is fairly unreactive toward CF3OF and gives low yields of substitution products.

Substituted amino acids

Esters and thiolesters of amino acids, intermediates therefor, synthesis thereof, and the use of said esters and thiolesters and compositions for the control of pests.