Nitrocycline

Base Information

• Chemical Name: Nitrocycline
• CAS No.: 5585-59-1
• Molecular Formula: C21H21 N3 O9
• Molecular Weight: 459.412
• Mol file: 5585-59-1.mol

Synonyms:2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-nitro-1,11-dioxo-(6CI,7CI,8CI); 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-nitro-1,11-dioxo-,[4S-(4a,4aa,5aa,12aa)]-;7-Nitro-6-demethyl-6-deoxytetracycline; 7-Nitrosancycline; Nitrocycline

Chemical Property of Nitrocycline

Chemical Property:

• Boiling Point: 691.9°Cat760mmHg
• Flash Point: 372.2°C
• PSA: 207.21000
• Density: 1.71g/cm³
• LogP: 1.25230

Purity/Quality:

99%, ^*data from raw suppliers

NITROCYCLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Antibacterial.

Technology Process of Nitrocycline

There total 3 articles about Nitrocycline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 7-Nitro-6-desmethyl-6-desoxy-tetracyclin (5585-59-1)

Guidance literature:

6-Desmethyl-6-desoxy-tetracyclin, HNO3/H2SO4; neben 9-Nitro-6-desmethyl-6-desoxy-tetracyclin;

DOI:10.1021/ja01489a064

Reference yield:

sancycline (808-26-4,2696-12-0,15964-02-0,39105-46-9) → [4S-(4a,12aα)]-7-nitro-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a octahydro-naphthacene-2-carboxylic acid amide (5585-59-1) + 9-nitro-6-demethyl-6-deoxytetracycline

Guidance literature:

With sulfuric acid; at 0 ℃; for 0.5h;

Reference yield:

sancycline (808-26-4,2696-12-0,15964-02-0,39105-46-9) → [4S-(4a,12aα)]-7-nitro-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a octahydro-naphthacene-2-carboxylic acid amide (5585-59-1)

Guidance literature:

With sulfuric acid; sodium nitrite;

upstream raw materials:

sancycline

Downstream raw materials:

7-amino-6-desmethyl-6-deoxytetracycline

Refernces

• 1、 -. "SUBSTITUTED TETRACYCLINE COMPOUNDS". Page 28. . Retrieved 2010/02/10.